Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE BCP first rearrange their immunoglobulin (Ig) heavy chain (IGH) genes to form the pre-B-cell receptor (pre-BCR) complex together with surrogate light chains. 31849931 2019
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia. 31243274 2019
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE At our institute, we incorporated the use of FGFR3/IGH dual-color dual-fusion DNA probes for confirmation of aneuploidy 4 and 14 in diagnostic B-ALL specimens. 27820126 2017
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE Molecular studies revealed clonal immunoglobulin heavy-chain (IGH) gene rearrangement within the HS, suggesting linkage to his previous B-ALL. 26574666 2015
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE B acute lymphoblastic leukemia with t(14;19)(q32;p13.1) involving IGH/EPOR: a clinically aggressive subset of disease. 24030742 2014
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE Our findings confirm that deregulated CEBPE plays a crucial role in the pathogenesis of CEBPE-IGH positive B-ALL. 22137487 2011
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE The T-cell epitopes encoded by the IgHV gene in the B-ALL patients were predicted by SYFPEITHI and BIMAS programs and compared with those from 56 representative germline IgHV sequences in the genebank. 15889252 2005
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE In a patient with precursor B-cell acute lymphoblastic leukemia (ALL) associated with eosinophilia that completely responded to induction chemotherapy, we assayed serial remission cerebrospinal fluid and bone marrow specimens for minimal residual disease using a quantitative polymerase chain reaction assay to assess for clone-specific immunoglobulin heavy-chain gene cluster (IGH) gene rearrangement. 12708906 2003
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE We show that the B cell blockage at the pro-B to pre-B cell transition is due to a large homologous deletion in the IGH locus encompassing the IGHM gene leading to the inability to form a functional pre-BCR. 12200606 2002
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE B-precursor ALL cases (especially stage IV of Nadler's criteria) have V-D-J rearranged IgH genes on both alleles. 1405717 1992
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 SomaticCausalMutation disease ORPHANET Kaplan-Meier plot analysis revealed no significant difference between adult precursor B-ALL patients with monoclonal or oligoclonal IgH gene rearrangements and their disease-free survival rates. 1554798 1992
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE No correlation was found between the immunophenotype of the ALL and the arrangement pattern of their IgH genes. 1554798 1992
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE DNA from 2 patients with pre-pre-B-ALL (CD10-) and 1 patient with common ALL contained rearranged Ig light chain (kappa in two, lambda in one case) in addition to rearranged IgH genes. 1850055 1991
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 AlteredExpression disease BEFREE As the detection limit of the Southern blot technique is 2-5%, it might well be that small subclones remained undetected, implying that the frequency of subclone formation at the IgH gene level in precursor B-ALL is probably higher than 40%. 1909409 1991
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE We have used a more sensitive, polymerase chain reaction based immunoglobulin gene 'fingerprinting' approach in the analysis of B-cell clonality in eight patients with common ALL which were apparently monoclonal on the basis of Southern blot analysis of their IgH genes. 1961017 1991