Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE However, based on currently available data, we propose that consolidative HCT post-CART therapy be considered for all HCT-eligible patients and especially for pediatric patients with KMT2A-rearranged B-cell acute lymphoblastic leukemia. 30973486 2019
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness and early relapse, and therefore new therapeutic targets are needed for relapsed/refractory MLLr-B-ALL. 30635633 2019
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE The pathogenesis of t(4;11)/KMT2A-AFF1<sup>+</sup> (MLL-AF4<sup>+</sup>) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure. 30679323 2019
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE These findings uncover MLL-dependent transcriptional activation of BCL6 as a previously unrecognized requirement of malignant transformation by oncogenic MLL fusions and identified BCL6 as a novel target for the treatment of MLL-rearranged B-ALL. 31395741 2019
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE We present a case of an infant who developed pro-B acute lymphoblastic leukemia with a rare and complex MLL-translocation. 30553463 2018
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 PosttranslationalModification disease BEFREE DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites. 27786413 2017
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Together, our data suggest that IGF2BP3-mediated targeting of oncogenic transcripts may represent a critical pathogenetic mechanism in MLL-rearranged B-ALL and support IGF2BP3 and its cognate RNA-binding partners as potential therapeutic targets in this disease. 26974154 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Despite the small cohort size, it could be postulated that B lineage ALL with MLL abnormalities and mature phenotype is a distinct entity that differs both from the typical Pro B ALL observed in infants and mature B-ALL with high MYC expression. 26857438 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive infant pro-B-acute lymphoblastic leukemia (B-ALL). 26837759 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. 26907630 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE However, rare cases of mature B-ALL with non-L3 morphology and MLL-AF9 fusion have been reported, and such cases are characterized by a rapid and aggressive clinical course. 27084248 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Conversely, the genome-wide mutational landscape in MLL-rearranged infant B-ALL has been reported silent. 27119507 2016
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Poor prognosis BCR-ABL and MLL-AF4 was detected in two-thirds of pediatric B-ALL and is likely to be the reason for the already reported poor survival of childhood ALL in South-East Asia. 26266519 2015
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE The genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene. 26463423 2015
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE To gain insight into the genomic landscape of infant MLL-AF4 pro-B ALL we performed whole genome sequencing of diagnostic leukemic blasts and matched germline samples from three MLL-AF4 pro-B ALL infants. 23893660 2013
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE Therapy-related pro-B cell acute lymphoblastic leukemia: report of two patients with MLL amplification. 23238285 2012
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE We present here a case of phenotypic precursor-B acute lymphoblastic leukemia (ALL), subsequently found to have both MYC and MLL translocations. 20829716 2011
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE We demonstrate that CRLF2 is overexpressed in approximately 15% of adult and high-risk pediatric B-ALL that lack MLL, TCF3, TEL, and BCR/ABL rearrangements, but not in B-ALL with these rearrangements or other lymphoid malignancies. 20018760 2010
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Recipients of AF4.MLL- or double-transduced LSPCs developed pro-B ALL, B/T biphenotypic acute leukemia, or mixed lineage leukemia. 20194896 2010
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Up-regulation of miR-196b coincides with reduced DNA methylation at CpG islands in the promoter regions of miR-196b and the entire HOXA cluster in MLL-rearranged cases compared to in cases of non-MLL precursor B-cell acute lymphoblastic leukemia and normal bone marrow (P<0.05), suggesting an epigenetic origin for miR-196b over-expression. 20494936 2010
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE These findings suggest that MSCs may be in part tumor-related, highlighting an unrecognized role of the BM milieu on the pathogenesis of MLL-AF4(+) B-ALL. 19995953 2009
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Differential expression of Ikaros isoforms in monozygotic twins with MLL-rearranged precursor-B acute lymphoblastic leukemia. 19131787 2008
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia. 16956839 2006
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 Biomarker disease BEFREE Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study. 17039234 2006
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
0.400 GeneticVariation disease BEFREE Our data identify CD10- cytoplasmic immunoglobulin-positive pre-B ALL as a rare (2.2%) but distinct immuno-subtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome. 16123216 2005