Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Testing for a TET2 mutation identified MPDs at the molecular level in another 7% of the subset of patients with BCS who were evaluated. 22467227 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE In 4 patients, mutations in TP53, CBL, or TET2 were present in JAK2 wild-type leukemic blasts but absent from the JAK2-mutant MPN. 20008300 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE The present study analyzed the TET2 gene in 61 MPN cases from 42 families. 19564637 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE In addition to JAK2 and TET2 mutations, which occur commonly in LT after MPN, we identified recurrent mutations in the serine/arginine-rich splicing factor 2 (SRSF2) gene (18.9%) in acute myeloid leukemia (AML) transformed from MPNs. 22431577 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE We observed that most patients with two MPNs harbored mutations in genes known to contribute to clonal hematopoiesis through altered epigenetic regulation such as TET2, ASXL1/2, SRSF2, and IDH2 at varying frequencies (1%-47%). 28335073 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE There was no evidence that JAK2 or TET2 mutations were associated with the type of MPN transformation, whereas the type of cytogenetic abnormalities were strongly linked, perhaps indicating that they play a specific role in the transformation process. 20629097 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Although TET2-mutations were thought to precede JAK2(V617F) in some persons with MPNs, it now appears that TET2 mutations may occur after JAK2(V617F). 21242185 2011
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE In conclusion, TET2 and ASXL1 pathogenic mutations are found in 8% of MPN lacking JAK2 and MPL mutations, whereas IDH1, IDH2, and c-CBL mutations are not detected in this subset of patients. 21904853 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes including chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML) and secondary AML (sAML). 21057493 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE TET2 mutations did not cluster in genetically defined MPN, CMML, or AML subsets but were associated with decreased overall survival in AML (P = .029). 19420352 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE We conclude that TET2 mutations occur in both JAK2V617F-positive and -negative MPN, are more prevalent in older patients, display similar frequencies across MPN subcategories and disease stages, and hold limited prognostic relevance. 19262601 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Altogether, we found a novel hereditary susceptible factor-TET2 rs3733609 C/T variant for the development of MPN, suggesting the variant may be partially responsible for the pathogenesis and accumulation of MPN. 26843622 2016
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Cases of myeloproliferative neoplasms (MPN) with TET2 mutations showed decreased levels of hydroxymethylation and distinct set of hypermethylated genes. 23066032 2013
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Our findings argue that the mutational order of events in MPN and sAML varies in different patients, and that TET2 and ASXL1 mutations have distinct roles in MPN pathogenesis and leukemic transformation. 20068184 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE We conclude that TET2 mutations occur in both JAK2 V617F-positive and -negative MPNs and are more frequent in MPN-U patients. 23781511 2013
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE We also identified a transcriptional signature of TET2 mutations in MPN patent samples. 24740812 2014
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes. 26697989 2016
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE Single nucleotide polymorphisms at various loci and somatic mutations, such as those in MPLW515L/K, TET2 and in exon 12 of JAK2, may also contribute to the pathogenesis of these MPNs. 19959098 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE There are likely additional somatic genetic factors important for the MPN phenotype like the recently described TET2, ASXL1, and CBL mutations. 20186505 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE This defect is rescued at the single HSC level by crossing JAK2V617F mice with mice lacking TET2, the most commonly comutated gene in patients with MPN. 29991556 2018
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE Mutations of <i>SF3B1</i> are commonly seen in myelodysplastic syndromes with ring sideroblasts (MDS-RS)and MDS/myeloproliferative neoplasm (MPN-RS-T). 31473630 2019
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE In this Review we discuss recent genetic and functional data implicating mutations in epigenetic modifiers, including tet methylcytosine dioxygenase 2 (TET2), isocitrate dehydrogenase 1 (IDH1), IDH2, additional sex combs-like 1 (ASXL1), enhancer of zeste homologue 2 (EZH2) and DNA methyltransferase 3A (DNMT3A), in the pathogenesis of MPN, MDS and AML, and discuss how this knowledge is leading to novel clinical, biological and therapeutic insights. 22898539 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE Beginning in early 2005, a number of novel mutations involving Janus kinase 2 (JAK2), Myeloproliferative Leukemia Virus (MPL), TET oncogene family member 2 (TET2), Additional Sex Combs-Like 1 (ASXL1), Casitas B-lineage lymphoma proto-oncogene (CBL), Isocitrate dehydrogenase (IDH) and IKAROS family zinc finger 1 (IKZF1) have been described in BCR-ABL1-negative MPNs. 20428194 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 PosttranslationalModification disease BEFREE In summary, methylation of TET2, CBL and CEBPA is infrequent in MPN at diagnosis. 20671051 2010