Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 AlteredExpression disease BEFREE Furthermore, significant overexpression of PDGFRB was found in a patient with an eosinophilia-associated myeloproliferative neoplasm with uninformative cytogenetics and an excellent response to imatinib. 20107158 2010
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE A 2.5-year-old boy was diagnosed with myeloproliferative disorder and eosinophilia associated with lymphoblastic lymphoma both bearing the CCDC88C-PDGFRB fusion. 30726835 2019
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE However, although the incidence of MPD involving translocations of PDGFRB has been well established, to our knowledge there are only two previous reports describing a BCR-PDGFRA fusion gene, in 3 patients diagnosed with atypical CML. 15034867 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Similarly, the drug has now been shown to display equally impressive therapeutic activity in eosinophilia-associated chronic myeloproliferative disorders that are characterized by activating mutations of either the PDGFRB or the PDGFRA gene. 15166033 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Chromosomal translocations involving the platelet-derived growth factor receptor beta gene (PDGFRB) have been reported in a subset of patients with atypical myeloproliferative disorders (MPDs). 18262053 2008
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. 28000100 2017
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Imatinib is usually a highly effective treatment for myeloproliferative neoplasms (MPNs) associated with ABL, PDGFRA or PDGFRB gene fusions; however, occasional imatinib-responsive patients have been reported without abnormalities of these genes. 18971950 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPNs) include BCR-ABL in chronic myelogenous leukemia (CML) and a spectrum of PDGFRA/B mutant proteins that are products of intra- (eg, FIP1L1-PDGFRA) or interchromosomal (eg, ETV6-PDGFRB) gene fusions. 19147089 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Here we describe two patients with MPD with eosinophilia and PDGFRB rearrangements, one of which was congenital. 22488677 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE We report the cloning of a novel PDGFRB fusion gene partner in a patient with a chronic myeloproliferative disorder characterized by t(5;14)(q33;q32), who responded to treatment with imatinib mesylate. 15496975 2005
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE BCR-ABL1 is associated with chronic myelogenous leukaemia (CML) and mutant PDGFR with an MPN phenotype characterized by eosinophilia and in addition, in case of FIP1L1-PDGFRA, bone marrow mastocytosis. 19175693 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE We sought to identify new fusion genes with involvement of the platelet-derived growth factor receptor beta gene (PDGFRB) in three patients presenting with various subtypes of chronic myeloproliferative disorders associated with chromosomal aberrations involving chromosome bands 5q31-33. 17296564 2007
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE The incidence of myeloproliferative neoplasms (MPN) with PDGFRB rearrangement was low (10 cases, 1.8% of all MPN). 22587685 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2). 19006078 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Imatinib mesylate has recently been shown to be efficacious in MPDs with PDGFR activation. 12907457 2003
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE In this study, we have tested nine patients with a CMPD or MDS/MPD and a translocation involving 5q31-33 for disruption of PDGFRB by two-colour fluorescence in situ hybridization (FISH) using differentially labelled, closely flanking probes. 12542482 2003
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Twelve patients with BCR-ABL-negative CMPDs and reciprocal translocations involving PDGFRB received imatinib for a median of 47 months (range, 0.1-60 months). 16960151 2007
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Important changes include (1) the change of nomenclature of myeloproliferative disorder to myeloproliferative neoplasm emphasizing the clonal nature of these disorders; (2) the classification of mast cell disease as an MPN; (3) the reorganization of the eosinophilic disorders into a molecularly defined category of PDGFRA, PDGFRB and FGFR1-associated myeloid and lymphoid neoplasms with eosinophilia and chronic eosinophilic leukemia, not otherwise specified; and (4) refinement of the diagnostic criteria for PV, ET and PMF incorporating recently described molecular markers, JAK2V617F, JAK2 exon 12 mutations and MPL mutations. 20191332 2010
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor beta-gene. 15477214 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. 15492236 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. 15087377 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE We report a NUMA1-PDGFRB fusion in a myeloproliferative neoplasm with eosinophilia in a 61-year old man, with response to imatinib mesylate therapy. 28449810 2017
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Here, we developed version 2.0 of a genomically based systematic kinase fusion screen and used it to detect a novel imatinib-sensitive C6orf204-PDGFRB fusion in a patient with precursor T lymphoblastic lymphoma (T-ALL) and an associated myeloproliferative neoplasm with eosinophilia. 21938754 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE The revised 2008 WHO classification system featured the following changes: 1) the term "CMPD" was replaced by "myeloproliferative neoplasm (MPN)," 2) mast cell disease was formally included under the category of MPN, and 3) the subcategory of CEL/HES was reorganized into "CEL not otherwise specified (CEL-NOS)" and "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1"; CEL-NOS remained a subcategory of "MPN," whereas the latter neoplasms were now assigned a new category of their own. 19472396 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease MGD