Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Hence, we examined a cohort of 123 myeloproliferative neoplasm (MPN) patients without BCR-ABL1 rearrangement and additional ET patients (n=96) for coexistence of JAK2 and CALR mutations. 27486987 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Molecular routine diagnostics for BCR-ABL1-negative myeloproliferative neoplasms (MPN) currently focusses on mutations in JAK2, CALR and MPL. 27447873 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. 15870860 2005
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Data on angiogenesis in the bone marrow of BCR-ABL1-negative myeloproliferative neoplasm (MPN) patients suggest an increase of the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression, but relations to the JAK2-V617F status remain controversial. 19466975 2009
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The Janus kinase (JAK)2 p.V617F gain-of-function mutation is a hallmark of BCR-ABL1-negative myeloproliferative neoplasms (MPNs). 26361084 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The majority of patients with BCR-ABL1-negative myeloproliferative neoplasms (MPN) harbor mutations in JAK2 or MPL, which lead to constitutive activation of the JAK/STAT, PI3K and ERK signaling pathways. 23748344 2013
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE TERT rs2736100_C polymorphism predisposes to the development of BCR-ABL1-negative MPN with the co-occurrence of solid tumors, especially with the usage of cytoreductive treatment. 26487696 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE JAK2V617F is sufficiently prevalent in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) to be useful as a clonal marker. 21723416 2011
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The discovery of JAK2V617F and other JAK-STAT-activating mutations in BCR-ABL1-negative myeloproliferative neoplasms (MPN) has led to the development of small-molecule ATP-mimetics that inhibit wild-type and mutant JAK. 21245760 2011
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The combined genetic tests of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR exon 9 help improve the diagnostic rate for BCR-ABL1-negative MPN. 26071474 2015
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm the hallmark of which, the breakpoint cluster region-Abelson (BCR-ABL) oncogene, has been the target of tyrosine kinase inhibitors (TKIs), which have significantly improved the survival of patients with CML. 31102734 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations. 23628959 2013
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE This case is the first report describing acquisition of secondary genetic events leading to acute lymphoblastic progression in a rare MPN with BCR-JAK2 fusion. 26935241 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE A small number of chronic myeloproliferative disorders with hematologic features of chronic myelomonocytic leukemia (CMML) or atypical chronic myeloid leukemia and Ph1 chromosome with m-BCR rearrangement have been reported (p190 CMPD). 10586207 1999
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE We report results of bcr analysis by Southern hybridization in 37 patients with MPDs other than CML: ET (20 cases), PV (seven cases). unclassified MPD (nine cases), as well as in one case of chronic myelomonocytic leukemia (CMML). bcr negativity ruled out CML in 36 cases, confirming the morphologic diagnosis.In one case diagnosed as ET. bcr gene rearrangement was diagnostic of CML. 8818385 1996
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Angiogenesis and JAK2 V617F mutation are common in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). 28554272 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE We discuss the role of immunotherapy in MPNs and the impact of the mutational landscape on TKI treatment in CML. 30074634 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Cytogenetic studies and molecular analysis of the bcr gene were performed in bone marrow cells of patients with CMPD simultaneously with histopathologic examination of plastic-embedded bone marrow biopsies. 7723278 1995
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Key genetic aberrations include the BCR-ABL1 gene rearrangement in Philadelphia chromosome-positive chronic myelogenous leukemia (CML) and JAK2/MPL/CALR aberrations in Philadelphia chromosome-negative MPNs. 29951914 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells, which fall into distinct categories based on a number of characteristics including the presence of the BCR-ABL1 gene fusion (chronic myelogenous leukemia) or the JAK2(V617F) mutation (polycythemia vera, primary myelofibrosis, and essential thrombocythemia). 22847163 2012
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Polycythaemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (MF), are the most common myeloproliferative neoplasms (MPN) in patients without the BCR-ABL1 gene rearrangement. 23986553 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Novel BCR-ABL1 fusion identified by targeted next-generation sequencing in a patient with an atypical myeloproliferative neoplasm. 24927924 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. 11746971 2001
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE These results demonstrate that STAT5a/b is essential for the induction of CML-like leukemia by BCR-ABL1 and of polycythemia by JAK2(V617F), and validate STAT5a/b and the genes they regulate as targets for therapy in these MPNs. 22234689 2012
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like). 30401948 2019