| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | In this context, the LNK inhibitory adaptor protein encoded by the LNK/SH2B adaptor protein 3 (SH2B3) gene is the target of several genetic variations, acquired or inherited in MPNs, lymphoid leukemia and nonmalignant hematological diseases, underlying its importance in these pathological processes. | 28484264 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | In this study, we observed the correlation between variation in LNK gene and the clinical type of myeloproliferative neoplasms (MPN). | 27111338 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Murine models show that loss of LNK enhances the development of MPNs and may have a role in additional pathologies. | 23045270 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | LNK deficiency promotes myeloproliferative neoplasm (MPN) development in mice, and LNK loss-of-function mutations are found in human MPNs, emphasizing its pivotal role in normal and malignant HSPCs. | 22546852 | 2012 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Here, we showed that LNK levels are up-regulated and correlate with an increase in the JAK2-V617F mutant allele burden in MPN patients. | 20870899 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | These findings indicate that JAK-STAT activation due to loss of LNK negative feedback regulation is a novel mechanism of MPN pathogenesis. | 20404132 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We conclude that LNK mutations (i) target an exon 2 'hot spot' in the PH domain spanning residues E208-D234, (ii) might be more prevalent in blast-phase PMF and (iii) are not mutually exclusive of other MPN-associated mutations but rarely occur in their presence in chronic-phase disease. | 20724988 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | The role of inhibitory pathways (e.g., SOCS and LNK) in regulating JAK-STAT signaling in MPNs is being increasingly recognized. | 21082983 | 2010 |