Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm primarily due to the presence of the BCR-ABL fusion gene that produces the constitutively active protein, BCR-ABL. 31837444 2020
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Venous thromboembolism (VTE) is a major burden in patients with BCR-ABL-negative myeloproliferative neoplasms (MPN). 30155552 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 AlteredExpression disease BEFREE Defining the presence of BCR-ABL transcript in suspected myeloproliferative neoplasm is essential in establishing chronic myeloid leukemia. 30772299 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase from 2 large institutions. 30594750 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of BCR-ABL fusion gene (GenBank accession NC_000022.11). 31206255 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Chronic neutrophilic leukemia (CNL) is a BCR-ABL1-negative myeloproliferative neoplasm with notably dismal survival. 30581159 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Co-occurrence of these disease entities is very rare and typically involves presence of common p190 or p210 BCR/ABL fusion transcript (responsible for CML) along with JAK2V617F mutation (most common driver mutation in Ph-negative MPNs). 30463063 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative disorder due to the existence of BCR-ABL fusion protein that allows the cells to keep proliferating uncontrollably. 31413564 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE <b>Introduction</b>: The abnormally activated JAK-STAT pathway plays a central role in the pathogenesis of BCR/ABL-negative myeloproliferative neoplasms (MPNs), simultaneously providing a theoretical and clinical basis for the development of small-molecule compounds targeting JAK. 31450973 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The objective of this review is to characterize studies on BCR-ABL1-negative chronic myeloproliferative neoplasms and to compare the frequency of JAK2, MPL and CALR mutations in PV, ET and PMF. 31208359 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR-ABL-negative myeloproliferative neoplasms (MPNs) are driven by JAK-STAT pathway activation, but epigenetic alterations also play an important pathophysiological role. 30769020 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The discovery of somatic mutations within the gene encoding calreticulin (CALR) in 2013 represented a major milestone in the molecular diagnosis of BCR-ABL negative myeloproliferative neoplasms (MPN). 28340692 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Primary myelofibrosis (PMF) is one of the classic BCR-ABL1 negative myeloproliferative neoplasms (MPN). 29256926 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE This review is based on the presentations and deliberations at the XIIth Post-ASH Workshop on BCR-ABL1 positive and negative MPNs that took place on December 12 to 13, 2017, in Atlanta, Georgia, immediately following the 59th American Society of Hematology Meeting. 30074634 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Key genetic aberrations include the BCR-ABL1 gene rearrangement in Philadelphia chromosome-positive chronic myelogenous leukemia (CML) and JAK2/MPL/CALR aberrations in Philadelphia chromosome-negative MPNs. 29951914 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR/ABL1-negative myeloproliferative neoplasms (MPNs) are characterized by recurrent mutations in JAK2, CALR, and MPL, each of which has been reported to alter JAK/STAT signaling pathways. 27258562 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms. 29466766 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Although from the literature review, the frequency of JAK2V617F mutation and BCR‑ABL translocation coexistence in MPNs is low, it may be higher than expected. 29845291 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22) (q34;q11.2) encoding for the BCR-ABL fusion oncogene. 30030958 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE CKD is prevalent in patients with BCR-ABL1-negative MPN. 28298076 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Mutations of JAK2V617F, JAK2 exon 12, MPL W515L/K and CALR were analysed in 439 Argentinean patients with BCR-ABL1-negative MPN, including 176 polycythemia vera (PV), 214 essential thrombocythemia (ET) and 49 primary myelofibrosis (PMF). 28990497 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Myeloproliferative neoplasm with ABL1/ETV6 rearrangement mimics chronic myeloid leukemia and responds to tyrosine kinase inhibitors. 30553471 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Angiogenesis and JAK2 V617F mutation are common in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). 28554272 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The management of pregnancy during the course of BCR-ABL1-negative myeloproliferative neoplasms (MPN) is an increasingly relevant problem. 30084669 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE A total of 492 BCR-ABL-negative MPN patients treated in our hospital from May 2013 to August 2016 were enrolled. 30084272 2018