Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 GeneticVariation disease BEFREE The purpose of this review is to provide an overview of the differential diagnosis for eosinophilia, to recommend specific steps for the pathologist evaluating blood and bone marrow, and to emphasize 2 important causes of eosinophilia that require specific ancillary tests for diagnosis: myeloproliferative neoplasm with PDGFRA rearrangement and lymphocyte-variant hypereosinophilic syndrome. 27684977 2017
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 GeneticVariation disease BEFREE This study also found losses at 11q13.3 in 26% of patients with MPN-Ph- and in 19p13.11 in two of the three patients with an MPN associated with a PDGFRA rearrangement. 24813417 2015
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 Biomarker disease BEFREE The fusion product of such genes is a tyrosine kinase oncoprotein sensitive to imatinib, which to date results to be the standard of care for FIP1L1-PDGFRA-positive chronic myeloproliferative disorders with eosinophilia. 24460680 2015
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 GeneticVariation disease BEFREE " The revised 2008 WHO classification system featured the following changes: 1) the term "CMPD" was replaced by "myeloproliferative neoplasm (MPN)," 2) mast cell disease was formally included under the category of MPN, and 3) the subcategory of CEL/HES was reorganized into "CEL not otherwise specified (CEL-NOS)" and "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1"; CEL-NOS remained a subcategory of "MPN," whereas the latter neoplasms were now assigned a new category of their own. 19472396 2009
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 AlteredExpression disease BEFREE This study demonstrates the utility of screening for PDGFRA kinase domain overexpression in patients with IHES and has identified a third PDGFRA fusion partner in chronic myeloproliferative disorders. 16498388 2006
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 GeneticVariation disease BEFREE Chronic myeloproliferative disorders with rearrangements of the platelet-derived growth factor receptor A (PDGFRA) gene at chromosome band 4q12 have shown excellent responses to targeted therapy with imatinib. 16845659 2006
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 Biomarker disease BEFREE Here, we report the molecular and cytogenetic characterization of a patient with BCR-PDGFRA-positive MPD who had a complete hematologic response after treatment with imatinib mesylate. 15034867 2004
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.080 GeneticVariation disease BEFREE Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec. 12944919 2003