Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE We report a NUMA1-PDGFRB fusion in a myeloproliferative neoplasm with eosinophilia in a 61-year old man, with response to imatinib mesylate therapy. 28449810 2017
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Here we describe two patients with MPD with eosinophilia and PDGFRB rearrangements, one of which was congenital. 22488677 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. 21938754 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE The incidence of myeloproliferative neoplasms (MPN) with PDGFRB rearrangement was low (10 cases, 1.8% of all MPN). 22587685 2012
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 AlteredExpression disease BEFREE Furthermore, significant overexpression of PDGFRB was found in a patient with an eosinophilia-associated myeloproliferative neoplasm with uninformative cytogenetics and an excellent response to imatinib. 20107158 2011
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Imatinib is usually a highly effective treatment for myeloproliferative neoplasms (MPNs) associated with ABL, PDGFRA or PDGFRB gene fusions; however, occasional imatinib-responsive patients have been reported without abnormalities of these genes. 18971950 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2). 19006078 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE " The revised 2008 WHO classification system featured the following changes: 1) the term "CMPD" was replaced by "myeloproliferative neoplasm (MPN)," 2) mast cell disease was formally included under the category of MPN, and 3) the subcategory of CEL/HES was reorganized into "CEL not otherwise specified (CEL-NOS)" and "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1"; CEL-NOS remained a subcategory of "MPN," whereas the latter neoplasms were now assigned a new category of their own. 19472396 2009
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE We sought to identify new fusion genes with involvement of the platelet-derived growth factor receptor beta gene (PDGFRB) in three patients presenting with various subtypes of chronic myeloproliferative disorders associated with chromosomal aberrations involving chromosome bands 5q31-33. 17296564 2007
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders. 16960151 2007
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease BEFREE Rearrangements involving PDGFRA and PDGFRB in eosinophilic chronic myeloproliferative disorders, and of fibroblast growth factor receptor 1 (FGFR1) in the 8p11 stem cell myeloproliferative syndrome constitute additional examples of specific genetic alterations linked to clonal eosinophilia. 16781488 2006
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor beta-gene. 15477214 2006
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE We report the cloning of a novel PDGFRB fusion gene partner in a patient with a chronic myeloproliferative disorder characterized by t(5;14)(q33;q32), who responded to treatment with imatinib mesylate. 15496975 2005
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. 12907457 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. 15087377 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. 15492236 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE However, although the incidence of MPD involving translocations of PDGFRB has been well established, to our knowledge there are only two previous reports describing a BCR-PDGFRA fusion gene, in 3 patients diagnosed with atypical CML. 15034867 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Similarly, the drug has now been shown to display equally impressive therapeutic activity in eosinophilia-associated chronic myeloproliferative disorders that are characterized by activating mutations of either the PDGFRB or the PDGFRA gene. 15166033 2004
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 GeneticVariation disease BEFREE Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders. 12542482 2003
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.300 Biomarker disease MGD