Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Altogether, we found a novel hereditary susceptible factor-TET2 rs3733609 C/T variant for the development of MPN, suggesting the variant may be partially responsible for the pathogenesis and accumulation of MPN. 26843622 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes. 26697989 2016
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE MDS/MPNs have clinicopathologic features of both MDS and MPN diseases. 24378705 2014
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE We also identified a transcriptional signature of TET2 mutations in MPN patent samples. 24740812 2014
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Cases of myeloproliferative neoplasms (MPN) with TET2 mutations showed decreased levels of hydroxymethylation and distinct set of hypermethylated genes. 23066032 2013
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE In this Review we discuss recent genetic and functional data implicating mutations in epigenetic modifiers, including tet methylcytosine dioxygenase 2 (TET2), isocitrate dehydrogenase 1 (IDH1), IDH2, additional sex combs-like 1 (ASXL1), enhancer of zeste homologue 2 (EZH2) and DNA methyltransferase 3A (DNMT3A), in the pathogenesis of MPN, MDS and AML, and discuss how this knowledge is leading to novel clinical, biological and therapeutic insights. 22898539 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Testing for TET2 mutations can identify another 7% of idiopathic BCS patients with molecular MPDs. 22467227 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE In addition to JAK2 and TET2 mutations, which occur commonly in LT after MPN, we identified recurrent mutations in the serine/arginine-rich splicing factor 2 (SRSF2) gene (18.9%) in acute myeloid leukemia (AML) transformed from MPNs. 22431577 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Although TET2-mutations were thought to precede JAK2(V617F) in some persons with MPNs, it now appears that TET2 mutations may occur after JAK2(V617F). 21242185 2011
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 PosttranslationalModification disease BEFREE In summary, methylation of TET2, CBL and CEBPA is infrequent in MPN at diagnosis. 20671051 2011
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes including chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML) and secondary AML (sAML). 21057493 2011
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE In 4 patients, mutations in TP53, CBL, or TET2 were present in JAK2 wild-type leukemic blasts but absent from the JAK2-mutant MPN. 20008300 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE Single nucleotide polymorphisms at various loci and somatic mutations, such as those in MPLW515L/K, TET2 and in exon 12 of JAK2, may also contribute to the pathogenesis of these MPNs. 19959098 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE There was no evidence that JAK2 or TET2 mutations were associated with the type of MPN transformation, whereas the type of cytogenetic abnormalities were strongly linked, perhaps indicating that they play a specific role in the transformation process. 20629097 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE Our findings argue that the mutational order of events in MPN and sAML varies in different patients, and that TET2 and ASXL1 mutations have distinct roles in MPN pathogenesis and leukemic transformation. 20068184 2010
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE The present study analyzed the TET2 gene in 61 MPN cases from 42 families. 19564637 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE TET2 mutations did not cluster in genetically defined MPN, CMML, or AML subsets but were associated with decreased overall survival in AML (P = .029). 19420352 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 GeneticVariation disease BEFREE We conclude that TET2 mutations occur in both JAK2V617F-positive and -negative MPN, are more prevalent in older patients, display similar frequencies across MPN subcategories and disease stages, and hold limited prognostic relevance. 19262601 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease BEFREE In this study, we have tested nine patients with a CMPD or MDS/MPD and a translocation involving 5q31-33 for disruption of PDGFRB by two-colour fluorescence in situ hybridization (FISH) using differentially labelled, closely flanking probes. 12542482 2003