| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | Δ<i>Hmga2</i>/<i>JAK2</i><sup>V617F</sup> cells showed a greater repopulating ability that reproduced the severe MPN compared with <i>JAK2</i><sup>V617F</sup> cells in serial bone marrow transplants, indicating that Hmga2 promotes MPN progression at the HSC level. | 29296743 | 2017 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Furthermore, the methylation changes in the direct target loci (FOXH1, HOXC9, and SRF) were clustered independently from the control locus (L1TD1) and other mutation genes (HMGA2 and Lin28A) in the analyzed MPN samples. | 29066347 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes. | 26697989 | 2016 | ||||
|
0.070 | Biomarker | disease | BEFREE | In conclusion, the frequently dysregulated MIRLET7/HMGA2 axis could be a therapeutic target in MPNs. | 25236537 | 2015 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm. | 22749035 | 2012 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Thus overexpression of HMGA2 leads to proliferative hematopoiesis with clonal expansion at the stem cell and progenitor levels and may account for the clonal expansion in PNH and MPNs and in gene therapy patients after vector insertion disrupts the HMGA2 locus. | 21460244 | 2011 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | In a MPD with t(3;12)(q29;q14), the rearrangement targeted the HMGA2 locus at 12q14 and deleted a region of about 1.5 megabases (Mb) at 3q29. | 17574970 | 2007 |