Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE High expression of feces COX-2 mRNA in colorectal adenomas and colorectal cancer is a common event; it is an early event in the development of colorectal adenomas to colorectal cancer. 28139497 2017
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 GeneticVariation disease BEFREE Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans. 19031967 2009
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 GeneticVariation disease BEFREE These results suggest that the C allele of COX2 8473 T > C polymorphism may interact with NSAIDs to reduce risk for colorectal adenoma. 19205707 2009
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 GeneticVariation disease BEFREE This study investigated the relation of COX-2 polymorphisms (-1195G>A, -765G>C and 8160A>G) to colorectal adenomas in a case-control study of male officials in the Self Defense Forces (SDF). 18167131 2008
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE To investigate expression of HuR in the colorectal adenoma-carcinoma sequence, we examined expression of HuR in colorectal mucosa of patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer with correlation to COX-2 expression. 18094611 2008
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE For the first time, we report that under hypoxic conditions COX-2 protein levels increase in colorectal adenoma and carcinoma cells. 16818642 2006
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE The results reported herein address the questions of what factors are associated with expression (relative messenger RNA levels) of COX-1 and COX-2 in colorectal adenomas and whether there is heterogeneity in the protective effect of NSAIDs by levels of COX expression. 15807932 2005
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 GeneticVariation disease BEFREE A protective effect on colorectal adenomas was found for the CT genotype of SNP H477H in PPARgamma and the GC genotype of SNP V102V in COX-2 (OR 0.63, 95% CI 0.45-0.89 and OR 0.65, 95% CI 0.46-0.92, respectively) compared with the homozygous major genotypes. 15550453 2005
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 Biomarker disease BEFREE The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the majority of cancers overexpressing COX-2; however, the role of COX-2 in the development of colorectal adenomas is less well defined. 12873979 2003
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 Biomarker disease BEFREE Taken together, our results suggest that overexpression of mPGES in addition to COX-2 contributes to increased amounts of PGE(2) in colorectal adenomas and cancer. 11751489 2001
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 PosttranslationalModification disease BEFREE Aberrant methylation of COX2 was also detected in 12 of 92 (13%) unselected sporadic primary colorectal cancers and 7 of 50 (14%) colorectal adenomas. 10945606 2000
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE An increase of COX-2-positive cells in adenoma was observed in 11 (37.9%) lesions, 10 (90.9%) of which had a K-ras gene mutation, suggesting a significant correlation between COX-2 expression and K-ras gene mutation in colorectal adenomas. 11129221 2000
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE In six pairs of colorectal adenomas and normal mucosa, three showed up-regulation of COX-2 in the adenoma compared with the normal mucosa. 7926468 1994