This meta-analysis suggests that the MTRA2756G polymorphism is not associated with CRC/CRA susceptibility and that gene-environment interaction may exist.
The GG genotype of MTRA2756G was associated with an increased risk of colorectal adenomas; odds ratios for AG and GG versus AA genotype were 0.99 (95% confidence interval 0.78-1.26) and 1.72 (1.04-2.82), respectively.
We also examined the relationship of a newly identified polymorphism (asp919gly) of the methionine synthase gene (MS) with the risk of colorectal adenomas in the same population.