Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and <i>in vivo</i> Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. | 28255344 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We therefore analyzed the pattern of CD44 standard and variant (v2-v10) transcripts in colorectal adenomas and carcinomas by exon-specific RT-PCR amplification and sought CD44v transcripts specific for colonic neoplasias. | 19787202 | 2009 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | We demonstrated by methylation-sensitive restriction enzyme digestion that the CpG islands of the CD44 promoter were methylated in 6/21 (28%) of benign colorectal adenomas. | 12782013 | 2003 | ||||
|
0.080 | Biomarker | disease | BEFREE | Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. | 10027409 | 1999 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | CD44 variant expression was investigated in normal colonic mucosa (n = 36), colorectal adenomas (n = 15), carcinomas (n = 62) and metastases (n = 6) by reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blotting with exon-specific probes. | 9893637 | 1998 | ||||
|
0.080 | Biomarker | disease | BEFREE | The aim of this study was to analyze the expression of CD44-messenger RNA (mRNA) in colorectal cancer and colorectal adenoma to further elucidate the role of CD44 in colorectal tumorigenesis. | 8566581 | 1996 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We generated DNA probes for CD44 variable region exons 11 (v6) to 14 (v9) and also for intronic sequences and examined the expression of aberrant CD44 transcripts in digestive tract carcinomas, colorectal adenomas and intestinal metaplasia of the stomach. | 8608952 | 1996 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation. | 7513984 | 1994 |