Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Furthermore, lumichrome potentially suppressed cancer stem cells (CSCs) in lung cancer by dramatically suppressing CSC markers together with the CSC-maintaining cell signaling namely protein kinase B (AKT) and β-catenin. 31074646 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Consistently, DOK7V1 overexpression in lung cancer cells suppressed the phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathways, but activated the focal adhesion kinase (FAK)/paxillin signaling pathway. 30431081 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Our findings suggested that SGA targets of the TGFβ/AKT/GSK3β axis played a key role in enhancing Slug degradation and suppressing lung cancer cells. 30732751 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE Furthermore, cotreatment with sesamin and CAY10404 markedly reduced the levels of phosphorylated protein kinase B (pAkt) and phosoinositide 3 kinase (PI3K) in three lung cancer cell lines. 30365050 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE Finally, we identified that the PI3K-AKT and epilthelial-mesenchymal transition (EMT) signaling pathways were inhibited by miR-3666 overexpression in lung cancer cells. 30481052 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Collectively, these results suggest that miR-411-5p/3p are required for NSCLC development by suppressing SPRY4 and TXNIP; thus, the miR-411-SPRY4-AKT axis might act as a promising target for lung cancer therapy clinically. 30390072 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE The combination of an AKT inhibitor and cisplatin efficiently suppressed lung cancer cell growth both <i>in vitro</i> and <i>in vivo</i> Our study illustrated an upstream regulatory mechanism of FEN1, which will contribute to the development of effective lung cancer therapies.These findings identified AKT as a regulator of FEN1 activity and revealed the AKT signaling pathway's contribution to drug resistance, which will contribute to the development of effective lung cancer therapy. 31467180 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Collectively, constitutive overexpression of Redd1 led to HSP27 and HSP70 induction and AKT activation, which were involved in lung cancer cell survival and resistance to IR, suggesting that Redd1 may be used as a therapeutic target for lung cancer. 30864724 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Co-mutations in <i>TP53</i> and the <i>PI3K/AKT/mTOR</i> pathway confer additional resistance to anti-HER2 treatments in lung cancer. 31748336 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Therefore, these findings revealed that LINC00511 functions as an oncogene via the PTEN/AKT/FOXO1 signaling pathway in lung cancer, providing a potential target of metastasis in lung cancer. 31415720 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Taken together, these findings demonstrate that PI3K/AKT/YY1 is involved in the regulation of lung cancer cell behavior induced by IL‑13, and miR‑29a represents a promising therapeutic target. 29620222 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Similar levels of miR‑29a and miR‑185 were detected in IPF and LC while their common targets AKT1 and DNMT3b were not found to differ, suggesting potential pathogenetic similarities at the level of key epigenetic regulators. 29568927 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE We showed that RBL2/p130 and AKT1 physically interact and AKT phosphorylates RBL2/p130 Ser941, located in the pocket domain, but not when this residue is mutated into Ala. We found that pharmacological inhibition of AKT, through the highly selective AKT inhibitor VIII (AKTiVIII), impairs RBL2/p130 Ser941 phosphorylation and increases RBL2/p130 stability, mRNA expression and nuclear levels in both lung cancer and mesothelioma cell lines, mirroring the more extensively studied effects on the p27 cell-cycle inhibitor. 29606701 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE The present results suggested that matrine inhibits lung cancer cell proliferation, and induces cell apoptosis by suppressing the Akt/GSK-3β signaling pathway, which demonstrated that matrine may have therapeutic potential for lung cancer. 30112033 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Icotinib enhances lung cancer cell radiosensitivity in vitro and in vivo by inhibiting MAPK/ERK and AKT activation. 29770473 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE INSM1 functions as a key player in NE lung cancer via Shh signaling that crosstalk with PI3K/AKT and MEK/ERK<sup>1/2</sup> pathway to enhance N-myc stability in NE lung cancer. 29501727 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 PosttranslationalModification disease BEFREE The novel hsa-miR-12528 regulates tumourigenesis and metastasis through hypo-phosphorylation of AKT cascade by targeting IGF-1R in human lung cancer. 29712908 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Mitochondrial dysfunction induces the invasive phenotype, and cell migration and invasion, through the induction of AKT and AMPK pathways in lung cancer cells. 29916527 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE TRIM37 targets AKT in the growth of lung cancer cells. 30510432 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. 30546837 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE In addition, the expression of SHP2, Ras, Akt1 and survivin was assessed by western blot analysis after the lung cancer cells were challenged by cisplatin or silenced by Ras siRNA. 29207183 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 PosttranslationalModification disease BEFREE Culturing A549, H1792 and H1975 lung cancer cell lines with the MARCKS ED peptide led to reduced levels of phosphorylated MARCKS and phosphorylated Akt serine/threonine kinase 1. 28454237 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE These findings not only shed light on the molecular mechanisms that are activated by aberrant signalling through the PI3K/AKT pathway in lung epithelial cells, but also contribute to the identification of previously unrecognised molecules whose regulation takes part in the development of lung cancer. 28662101 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE Here, we utilize a bioluminescence reporter for AKT kinase activity (BAR) to noninvasively assess the therapeutic efficacy of the EGFR inhibitor erlotinib in KRAS-mutated lung cancer therapy. 28285180 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction. 28714963 2017