Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The detection of anti-p53 antibodies indicates that p53 is altered in amount, type or presentation in breast tumors so that it becomes immunogenic. 6292117 1982
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group CTD_human The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. 26229107 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G>C) and MDM2 SNP309 (-410T>G), and p53 protein expression in breast tumors on survival. 20021639 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE A higher prevalence of p53 mutations was found in the breast tumors of current smokers (36.5%; P = 0.02) compared with never smokers (23.6%), whereas fewer mutations were found in former smokers (16.2%; P = 0.09). 11929815 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN TP53 mutations in breast cancer: association with ductal histology and early relapse of disease. 18949740 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group CLINVAR Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer. 9569050 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. 19147582 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE This prognostic value may rely in part on the fact that p53 plays a role in the antiproliferative and apoptotic activities of chemotherapy regimens used to treat breast tumors. 20549698 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer. 18230179 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status. 18348141 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN TP53 mutations in synchronous and metachronous bilateral breast carcinomas. 18617062 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group LHGDN Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the risk of breast cancer: a case control study from South India. 17696741 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE The frequency of abnormalities affecting chromosome 17p and the TP53 gene was determined in 27 breast tumours from 26 female patients carrying the Icelandic BRCA2 founder mutation (999del5). 9467939 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE In summary, a new sensitive and quantitative LIA suitable for routine analysis of p53 protein in steroid receptor cytosol preparations from breast tumours has been developed to confirm the prognostic importance of p53 protein accumulation in human breast cancer. 7734292 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE We report here a rapid and robust induction of maspin expression in prostate cancer cells (LNCaP, DU145, and PC3) and breast tumor cells (MCF7) following wild type p53 expression from an adenovirus p53 expression vector (AdWTp53). p53 activates the maspin promoter by binding directly to the p53 consensus-binding site present in the maspin promoter. 10692390 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE This work indicates that functional inactivation of the wild-type p53 protein and of the product of a gene located on 17q are essential to the development of breast neoplasms. 8137297 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Our results in male breast tumors indicate a positive correlation between p53 mutation and p53 protein overexpression, whereas the results in female breast tumors indicate an overexpression of p53 protein even without p53 gene mutation. 8996549 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group LHGDN p53 status and efficacy of primary anthracyclines/alkylating agent-based regimen according to breast cancer molecular classes. 18325917 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Breast-cancer stromal cells with TP53 mutations and nodal metastases. 18094375 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE These protective effects of FR on survival and tumor incidence were paralleled by higher expression of the tumor suppressor gene p53 (wild type) and free-radical scavenging enzymes (catalase and superoxide dismutase) in breast tumors. 7604020 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE This study aimed to objectively determine optimal thresholds for p53 positivity by manual and automated scoring methods using whole tissue sections from the Carolina Breast Cancer Study. p53-immunostained slides were available for 564 breast tumors previously assayed for TP53 mutations. 26200835 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Furthermore, Notch-induced transcriptomes from p53 wild-type and -mutated breast tumor cell lines differed extensively, and for a subset of genes upregulated by Notch in a p53-mutant cell line, this upregulation was reduced by wild-type p53. 23178494 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The literature suggests that it is now appropriate to start assessing the p53 gene status of breast tumors for prognosis. 7664481 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Here we describe the analysis of BRCA1, PTEN, and p53 at the single cell level in 55 BRCA1-associated breast tumors and computational methods to predict the relative temporal order of somatic events, on the basis of the frequency of cells with single or combined alterations. 22628410 2012