Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 121838
Gene Symbol: NRAD1
NRAD1
0.010 Biomarker group BEFREE ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells. 31197235 2020
Entrez Id: 10713
Gene Symbol: USP39
USP39
0.010 Biomarker group BEFREE USP39 c.*208G > C was strongly associated with triple-negative breast tumors (p = 0.0001). 31754952 2020
Entrez Id: 50616
Gene Symbol: IL22
IL22
0.010 GeneticVariation group BEFREE Mechanistically, deletion of IL-22 gene causes downregulation of epithelial-to-mesenchymal transition (EMT)-associated transcription factors in breast tumors, suggesting EMT as the mechanism of regulation of malignancy by IL-22. 31725949 2020
Entrez Id: 693223
Gene Symbol: MIR638
MIR638
0.010 AlteredExpression group BEFREE The miR-638 overexpression inhibited the breast tumor growth. 31410735 2020
Entrez Id: 8899
Gene Symbol: PRPF4B
PRPF4B
0.010 AlteredExpression group BEFREE The splicing factors PRPF4B and BUD31 and the transcription factor BPTF are essential for cancer cell migration, amplified in human primary breast tumors and associated with metastasis-free survival. 31278301 2019
Entrez Id: 1718
Gene Symbol: DHCR24
DHCR24
0.010 Biomarker group BEFREE Breast tumor segmentation based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a challenging problem and an active area of research. 30130181 2019
Entrez Id: 81631
Gene Symbol: MAP1LC3B
MAP1LC3B
0.010 AlteredExpression group BEFREE Further, we provide the first evidence supporting the existence of a subset of breast tumors co-expressing ULK1 and MAP1LC3B (microtubule associated protein 1 light chain 3 beta) proteins. 30335599 2019
Entrez Id: 79707
Gene Symbol: NOL9
NOL9
0.010 AlteredExpression group BEFREE The expression of NET-6 was also stronger in HER2-negative, low-grade, lymphovascular invasion-negative, and non-metastatic breast tumors. 31004251 2019
Entrez Id: 1056
Gene Symbol: CEL
CEL
0.010 AlteredExpression group BEFREE The validation in GEO datasets also showed that CEL expression was higher in breast tumor tissues than in normal breast tissues. 31561066 2019
Entrez Id: 23642
Gene Symbol: SNHG1
SNHG1
0.010 Biomarker group BEFREE In vivo, SNHG1 knockdown decreased breast tumor growth. 31354360 2019
Entrez Id: 55353
Gene Symbol: LAPTM4B
LAPTM4B
0.010 AlteredExpression group BEFREE We investigated the influence of LAPTM4B expression on MCF-7 cell proliferation, invasion, adhesion, and tube formation abilities <i>in vitro</i> through its overexpression or knockdown and on breast tumor progression <i>in vivo</i>. 31598338 2019
Entrez Id: 23408
Gene Symbol: SIRT5
SIRT5
0.010 AlteredExpression group BEFREE Elevated SIRT5 expression in human breast tumors correlates with poor patient prognosis. 31843902 2019
Entrez Id: 10419
Gene Symbol: PRMT5
PRMT5
0.010 AlteredExpression group BEFREE We find that PRMT5 mRNA and protein are expressed at comparable levels in TNBC, luminal breast tumors, and healthy mammary tissues. 30957988 2019
Entrez Id: 10036
Gene Symbol: CHAF1A
CHAF1A
0.010 Biomarker group BEFREE Nano-strategies for CAF targeting profoundly contribute to enhance chemosensitivity of breast tumors, enabling access of cytotoxic T-cells and reducing immunosuppressive signals. 30871158 2019
Entrez Id: 50649
Gene Symbol: ARHGEF4
ARHGEF4
0.010 GeneticVariation group BEFREE Mutations in ARHGEF4 have been reported in breast tumors, but this is the first report of possible breast cancer-related DNA methylation changes. 30821641 2019
Entrez Id: 346389
Gene Symbol: MACC1
MACC1
0.010 Biomarker group BEFREE Here, we report that MACC1-AS1, a cognate antisense lncRNA of the sixth intron of the MACC1 gene, functions as a cell growth modulator and enhances breast tumor progress. 31822653 2019
Entrez Id: 729230
Gene Symbol: CCR2
CCR2
0.010 Biomarker group BEFREE CRISP/R gene ablation of <i>CCR2</i> in MCF10CA1d breast cancer cells inhibited breast tumor growth and M2 macrophage recruitment and validated through CCR2 shRNA knockdown in the 4T1 model. 30446625 2019
Entrez Id: 406962
Gene Symbol: MIR186
MIR186
0.010 Biomarker group BEFREE Together, our results reveal a novel molecular mechanism of resistance to hormone therapies in which the miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in ER-positive breast cancer, suggesting targeting miR-186-3p as a promising strategy for therapeutic intervention in endocrine-resistant breast tumors. 30967627 2019
Entrez Id: 115209
Gene Symbol: OMA1
OMA1
0.010 Biomarker group BEFREE These changes significantly increase migratory properties in metastatic breast cancer cells, indicating that OMA1 plays a critical role in suppressing metastatic competence of breast tumors. 31611601 2019
Entrez Id: 100507428
Gene Symbol: LINC00458
LINC00458
0.010 AlteredExpression group BEFREE In summary, for the first time, we found that lncRNA ES3 was significantly upregulated in HER2-positive breast tumors and may contribute to breast cancer proliferation as a downstream target of HER2. 31211468 2019
Entrez Id: 100874041
Gene Symbol: MACC1-AS1
MACC1-AS1
0.010 Biomarker group BEFREE Here, we report that MACC1-AS1, a cognate antisense lncRNA of the sixth intron of the MACC1 gene, functions as a cell growth modulator and enhances breast tumor progress. 31822653 2019
Entrez Id: 57620
Gene Symbol: STIM2
STIM2
0.010 Biomarker group BEFREE Knockdown of STIM2 inhibited the motility of breast cancer cells by inhibiting EMT via specific suppression of NFAT1 and inhibited mammary tumor metastasis in mice. 31464639 2019
Entrez Id: 3110
Gene Symbol: MNX1
MNX1
0.010 AlteredExpression group BEFREE MNX1-AS1 and its natural sense transcript MNX1 are expressed synergistically in breast tumor tissues. 30697072 2019
Entrez Id: 8611
Gene Symbol: PLPP1
PLPP1
0.010 AlteredExpression group BEFREE Consequently, increasing LPP1 levels suppresses breast tumor growth and metastasis. 31534541 2019
Entrez Id: 7130
Gene Symbol: TNFAIP6
TNFAIP6
0.010 Biomarker group BEFREE Taken together, these results indicate that the effect of high-molecular weight hyaluronan as an inductor of the angiogenic behavior of macrophages in breast tumor context is in part consequence of the presence of TSG-6. 31044513 2019