Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Additionally, associations were found for EGFR variations in lung tumors and PIK3CA variations in breast tumors. 31100334 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE Consistent with in vitro results, UNC5A expression negatively correlated with EGFR expression in breast tumors, and lower expression of UNC5A, particularly in ERα<sup>+</sup>/PR<sup>+</sup>/HER2<sup>-</sup> tumors, was associated with poor outcome. 29720215 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour biology. 30367623 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Using immunohistochemistry (IHC), we quantified the expression of ER, PR, HER2, the proliferation marker Ki67, and two basal-like biomarkers, epidermal growth factor receptor (EGFR) and cytokeratin (CK)5/6, in 1381 invasive breast tumors from African American women. 29409530 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Primary breast tumor FDG uptake is strongly influenced by EGFR status beyond that by other major biomarkers including hormone receptor and HER2 status, and EGFR expression is a strong independent predictor of high breast tumor FDG uptake. 28488029 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Here, we show that EGFR promotes breast tumor growth and metastasis by downregulating the tumor suppressor micoRNA-338-3p (miR-338-3p) and activating the EYA2 (EYA transcriptional coactivator and phosphatase 2) oncoprotein. 28703807 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Application of these signatures to breast tumor gene expression data identified two novel discrete phenotypes characterized by concordant, aberrant activation of either the HER2, IGF1R, and AKT pathways ("the survival phenotype") or the EGFR, KRAS (G12V), RAF1, and BAD pathways ("the growth phenotype"). 28446242 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE We previously identified a class of compounds we termed Disulfide bond Disrupting Agents (DDAs) that selectively kill EGFR+ and HER2+ breast cancer cells in vitro and blocked the growth of HER2+ breast tumors in an animal model. 28423644 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE By adding modifications to the established EGFR kinase inhibitor gefitinib, an approach to small molecule conjugates with a unique nuclear-targeting peptoid sequence was tested in both human and murine breast tumor cell models for their capacity to inhibit EGF-stimulated activation of ERK1/2 and STAT3. 28787571 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE In both cell lines and primary patient samples, we observed consistent expression patterns of these biomarkers varies by cancer indication, such that ERBB3 and CDKN1B expression are relatively high in breast tumors while EGFR expression is relatively high in other indications. 27035903 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE Furthermore, the experiments of in vivo tumor therapy confirmed that intravenous administration of T7-LPC/siEGFR NPs led to an effective EGFR down-regulation and an obvious inhibition of breast tumor growth, with little activation of immune responses and negligible body weight loss. 27355138 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Compared with MENA, higher levels of the prometastatic MENA(INV) isoform associate with α5, which enables 3-D haptotaxis of tumor cells toward the high FN concentrations typically present in perivascular space and in the periphery of breast tumor tissue. 26811325 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE For example, CDH3 was significantly up-regulated in the stromals of both breast and prostate tumors, however EGFR was only significantly down-regulated in the stromal of breast tumor. 25826086 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE On the other hand, although low-grade gliomas and glioblastomas, both brain cancers, driven by EGFR amplifications are highly functionally similar, their functional footprints are significantly different from lung and breast tumors driven by EGFR or ERBB2. 24166508 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group CTD_human Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. 23867902 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE Because activating mutations in this kinase are very rare events in breast cancer, we screened breast tumor gene expression profiles to examine the distribution of EGFR ligand expression. 23729230 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE In conclusion, our results indicated for the first time a regulatory role of ER-α36 in up-regulation of EGFR expression and down-regulation of ER-α66 expression, which could be an underlying mechanism for the growth status switch in breast tumors that contribute to the generation of acquired TAM resistance. 23499324 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Finally, we detect strong correlation between the level of anti-ADAM12L and anti-phospho-EGFR immunostaining in human breast tumors using tissue microarrays. 22926263 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE An inverse correlation between VPS4B expression and EGFR abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression. 22252323 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. 23129656 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Employing EGFR inhibition with erlotinib specifically at this premalignant stage was effective in decreasing the incidence of ER-negative breast tumors in this mouse model. 21396117 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Seventy samples were randomly chosen from a cohort of 653 triple negative breast tumours for EGFR mutation analysis. 21457545 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group CTD_human Immunophenotypic predictive profiling of BRCA1-associated breast cancer. 20941507 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE EGFR expression and activation are common in HER2 positive and triple-negative breast tumours. 20607659 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group CTD_human Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up. 20135347 2010