Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group CTD_mouse Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770 2014
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group CTD_human Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. 23548910 2013
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group BEFREE Promotion of metastasis in response to miR-224 downregulation was associated with derepression of the stroma-associated RKIP target genes, CXCR4, MMP1, and OPN, which are involved in breast tumor metastasis to the bone. 22809510 2012
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 AlteredExpression group BEFREE Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. 22011282 2011
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group BEFREE Both a MMP-1 inhibitor and P1pal-7 significantly promote apoptosis in breast tumor xenografts and inhibit metastasis to the lungs by up to 88%. 19622769 2009
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 AlteredExpression group LHGDN Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material. 17669621 2008
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group LHGDN Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. 18366705 2008
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group LHGDN High MMP-1 mRNA expression is a risk factor for disease-free and overall survivals in patients with invasive breast carcinoma. 17663001 2008
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 GeneticVariation group LHGDN Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer. 16267613 2006
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group BEFREE MMP-1 (interstitial collagenase) has been associated with MDA-MB-231 invasion in vitro, while MMP-3 (stromelysin-1) has been localised around invasive cells of breast tumours in vivo. 16430785 2006
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group BEFREE We conclude that MMP-1 expression is essential for the ability of MDA-231 cells to invade and destroy a collagen matrix and in vivo experiments suggest an important role for MMP-1 in breast tumor growth. 16322260 2005
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 Biomarker group LHGDN Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells. 16168111 2005
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 GeneticVariation group LHGDN An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer. 15149160 2004
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 AlteredExpression group LHGDN The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells. 14692651 2003
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.600 AlteredExpression group BEFREE The levels of the matrix metalloproteinase MMP1 mRNA in three breast tumour cell lines with varying numbers of epidermal growth factor (EGF) receptors, MDA-MB-231, T47D and MCF7, were investigated following treatment with EGF or TGF alpha in serum-free medium for up to 24 h. A higher level of MMP1 mRNA was found in both control and treated MDA-MB-231 cells compared with the other two cell lines. 9014756 1996