Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group BEFREE In this study, we aimed to investigate promoter methylation of three tumor-suppressor genes (BRCA-1, MGMT, and P16) and three histone marks (H3K9ac, H3K18ac, and H4K20me3) in patients with breast tumors. 30938887 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Here we present a systematic genomic analysis of breast tumors with BRCA1 and BRCA2 mutations. 31182087 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Breast tissues obtained from healthy women who breastfed for < 6 months vs ≥ 6 months showed significant enrichment of Notch signaling pathway genes, along with a trend for enrichment for luminal progenitor gene signature similar to what is observed in BRCA1 mutation carriers and basal-like breast tumors. 31315645 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 PosttranslationalModification group BEFREE Of the 141 breast tumors, 45 samples (32%) had high HRD scores and were associated with high histological grade (P = 0.001), negative progesterone receptor (P = 0.018), high Ki67 index (P = 0.032), and BRCA1 promoter methylation (P = 3.6e-07). 30607631 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Homologous recombination deficiency conferred by alterations in BRCA1 or BRCA2 are common in breast tumors and can drive sensitivity to platinum chemotherapy and PARP inhibitors. 31499327 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE In this review, we use the Microcompetition Model to explain how certain latent viruses, which are frequently detected in breast cancer tumors, can decrease the expression of the BRCA1 gene and cause the development of breast tumors. 30579323 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 AlteredExpression group BEFREE These cumulative data support the hypothesis that exposure to AsIII may contribute to reducing the efficacy of endocrine therapy against ERα‑positive breast tumors by hampering the expression of ERα and BRCA1 via CpG methylation, respectively of ESR1 and BRCA1. 30664189 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Targeting the β-hCG-HSP90-TGFBRII axis could prove an effective treatment strategy for BRCA1-mutated breast tumors. 30963174 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE We studied the breast tumor profile associated to the c.3481_3491del11 French founder effect mutation on the BRCA1 gene to an attempt to identify any particularity or difference when comparing it to that related to other BRCA1 mutations. 29550896 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 PosttranslationalModification group BEFREE We retrained and validated a copy-number-based support vector machine (SVM) classifier to identify HR-deficient, BRCA1-like breast tumors. 30683142 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Although ATM is involved in the DNA damage response, ATM-associated tumours are distinct from BRCA1-associated tumours in terms of morphological characteristics and genomic alterations, and they are also distinguishable from sporadic breast tumours, thus opening up the possibility to identify ATM variant carriers outside the ataxia-telangiectasia disorder and direct them towards effective cancer risk management and therapeutic strategies. 29665859 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group BEFREE Hormonal replacement experiments in ovariectomized mice showed that BRCA1-deficient mammary tumor formation is promoted by estrogen but not by progesterone. 29877575 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 PosttranslationalModification group BEFREE Corresponding tumour-derived DNA available from 5 of these 7 women had elevated methylation within the BRCA1 and SPHK2 promoter region and decreased methylation within the ADAP1, IGF2BP3 and SPATA13 promoter region when compared with the other breast tumours. 30423315 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE We identified 140 differentially expressed miRNAs, 9 of which were also differentially expressed in human BRCA1 breast tumours or familial non-BRCA1 patients and during normal gland development. 30323900 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group BEFREE Breast tumors deficient in BRCA1 are mostly associated with basal-like breast cancers and targeted therapeutics for this disease subtype are still lacking. 29938573 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE In this paper, we focus our interest on the dynamics alterations of the tumor-stroma interface at the ultrastructural level and to detect BRCA1 and BRCA2 mutations using next generation sequencing (NGS) of breast tumor tissue. 28730229 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE The increased propensity of BRCA1 mutation carriers to develop aggressive breast tumors with stem-like properties begins to be understood in terms of osteoprotegerin (OPG)-unrestricted cross-talk between RANKL-overproducing progesterone-sensor cells and cancer-initiating RANK<sup>+</sup> responder cells that reside within pre-malignant BRCA1<sup>mut/+</sup> breast epithelial tissue. 28387573 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Retention of the normal BRCA1 or BRCA2 allele (absence of locus-specific loss of heterozygosity (LOH)) is observed in 7% of BRCA1 ovarian, 16% of BRCA2 ovarian, 10% of BRCA1 breast, and 46% of BRCA2 breast tumors. 28831036 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group BEFREE Overall, our findings highlight a critical role of Rak in the maintenance of genomic stability, at least in part, through protecting BRCA1 and provide novel treatment strategies for patients with breast tumors lacking Rak. 29156836 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE Using genetic mouse-models, we and others identified the RANKL/RANK system as a key regulator of sex hormone, BRCA1-mutation, and oncogene-driven breast cancer and we proposed that RANKL/RANK might be involved in the initiation of breast tumors. 28002811 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group BEFREE The fate of BRCA1-related germline mutations in triple-negative breast tumors. 28123851 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group CTD_human A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. 28825726 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group BEFREE Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. 28649985 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 Biomarker group BEFREE In conclusion, proteome profiling of secretome using murine breast tumor models is a powerful strategy to identify non-invasive candidate biomarkers of BRCA1-deficient breast cancer. 27566577 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.500 GeneticVariation group CLINVAR Prevalence and Prognostic Role of BRCA1/2 Variants in Unselected Chinese Breast Cancer Patients. 27257965 2016