Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group BEFREE One factor, which may drive ongoing matrix synthesis in breast tumors, is the loss of stromal caveolin-1 (cav-1), a scaffolding protein of caveolae, which has been linked to breast tumor aggressiveness. 28187162 2017
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 PosttranslationalModification group BEFREE Cav1 CGI shore methylation was also observed in human breast tumors, and overall survival rates of breast cancer patients lacking estrogen receptor α (ERα) negatively correlated with Cav1 expression. 23128390 2013
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group CTD_human Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. 21501481 2011
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group CTD_human Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. 20562527 2010
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group CTD_human Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. 19288272 2010
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group LHGDN Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. 19234134 2009
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group CTD_human Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. 19234134 2009
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 AlteredExpression group BEFREE Importantly, in vivo experiments employing xenograft tumor models demonstrated that expression of caveolin-1 results in significant growth inhibition of breast tumors. 18778685 2008
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 GeneticVariation group LHGDN Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells. 18296864 2008
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 PosttranslationalModification group LHGDN Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. 17190831 2007
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 AlteredExpression group LHGDN Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. 17935714 2007
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group LHGDN Caveolin-1 expression is associated with a basal-like phenotype in sporadic and hereditary breast cancer. 16541313 2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 AlteredExpression group LHGDN Albumin-bound paclitaxel, ABI-007 may show better efficacy than paclitaxel in basal-like breast cancers: association between caveolin-1 expression and ABI-007. 16897435 2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 AlteredExpression group LHGDN Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer. 16244790 2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 AlteredExpression group LHGDN Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. 15592498 2005
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 PosttranslationalModification group LHGDN Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers. 15375584 2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group BEFREE This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058 2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group LHGDN This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058 2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group BEFREE We investigated the function of caveolin-1 protein in breast tumors. 14506991 2003
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker group BEFREE Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo. 10086342 1999