Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE The human epidermal growth factor receptor 2 (HER2)/receptor tyrosine-protein kinasebB-2 (ERBB2) is overexpressed in 20-30% of breast tumors leading to faster growing and more aggressive tumors. 27935425 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 Biomarker group BEFREE PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses. 28003307 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 Biomarker group BEFREE Estrone (E1), the major circulating estrogen in postmenopausal women, promotes estrogen-receptor positive (ER+) breast tumor growth and proliferation. 28429243 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 AlteredExpression group BEFREE Nearly 75% of breast tumors express estrogen receptor (ER), and will be treated with endocrine therapy, such as selective estrogen receptor modulator (SERM), tamoxifen, or aromatase inhibitors. 28396978 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 AlteredExpression group BEFREE Patients with breast tumors that do not express the estrogen receptor, the progesterone receptor, nor Her-2/neu are hence termed "triple negatives", and generally have a poor prognosis, with high rates of systemic recurrence and refractoriness to conventional therapy regardless of the choice of adjuvant treatment. 29145974 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.700 Biomarker group CTD_human A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. 28825726 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 Biomarker group BEFREE Furthermore, we show frequent transcript isoform changes in breast tumors according to ER status, and in melanoma tumors according to the invasive or proliferative phenotype, and derive accurate predictive models of stage and survival within each patient subgroup. 27535130 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 AlteredExpression group BEFREE Our aim was to document the subtypes defined by immunohistochemistry (IHC) expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2): namely ER + PR+ HER2+; ER + PR + HER2-; ER-PR-HER2+; and ER-PR-HER2- in metastatic breast carcinoma in pleural fluid and compare them with their expression in the primary breast tumor. 27666130 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.700 GeneticVariation group CLINVAR Prevalence and Prognostic Role of BRCA1/2 Variants in Unselected Chinese Breast Cancer Patients. 27257965 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.700 CausalMutation group CLINVAR Prevalence and Prognostic Role of BRCA1/2 Variants in Unselected Chinese Breast Cancer Patients. 27257965 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 GeneticVariation group BEFREE Moreover, AKT1(E17K) prevents HER2-driven mammary tumor formation, in part through negative feedback inhibition of RTK signaling. 27004402 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE For HR-/HER2+ breast tumor patients, the 3-year LRR rate was still lower for the cohort with trastuzumab (4.7% vs 8.6%). 27512838 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 AlteredExpression group BEFREE Multimodal Assessment of Estrogen Receptor mRNA Profiles to Quantify Estrogen Pathway Activity in Breast Tumors. 27756582 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group BEFREE Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors. 28031413 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.700 AlteredExpression group BEFREE Together, our results identify a novel mechanism regulating GPCR-dependent activation of the PI3K/AKT signaling axis in breast tumor cells, and pinpoint WDR26 as a potential therapeutic target for breast cancer. 26895380 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE ER, PR, and HER2 were determined by IHC in the primary breast tumor and the cell blocks of the pleural fluid with metastatic carcinoma. 27666130 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.700 Biomarker group CTD_human A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. 28825726 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 AlteredExpression group BEFREE About 75-80% of breast tumors express the estrogen receptor alpha (ER-α) and are treated with endocrine-target therapeutics, making this the premier therapeutic modality in the breast cancer clinic. 28320353 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE An interesting association was found between ER/PR (Oestrogen/Progesterone receptor) and HER2/Neu (Human epidermal growth factor receptor-2) positivity with HPV occurrence in breast tumours. 27613186 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group BEFREE Our data indicate that the use of anti-HER2 therapy should not be suggested unless true evaluation of HER2 protein expression is made regarding gene amplification essentially in IHC-ambiguous invasive breast tumors. 26738861 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.700 CausalMutation group CLINVAR Prevalence and Prognostic Role of BRCA1/2 Variants in Unselected Chinese Breast Cancer Patients. 27257965 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE Estrogen, progesterone, and HER2/neu receptor discordance between primary and metastatic breast tumours-a review. 27405651 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.700 Biomarker group BEFREE Combinatorial strategy may hold promise in development of therapies and chemoprevention strategies against ER-positive breast tumors, even those with acquired resistance to the drug. 26014809 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE We prepared single-cell suspensions, which were sorted using flow cytometry from breast tumor tissue and adjacent normal breast tissue from two HER2-positive patients. 27629143 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE In the METABRIC dataset, BAG-1 mRNA was significantly elevated in HER2+ breast tumors and predicted overall survival in a multivariate analysis (HR = 0.81; p = 0.022). 26958811 2017