Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE Taken together, our findings demonstrate that the anti-proliferation effect of GEN-27 in vitro and the prevention of CAC in vivo is mediated by p65-CDX2-β-catenin axis via inhibiting β-catenin target genes. 26910375 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 AlteredExpression disease BEFREE Previously, we identified the neural immunoglobulin-like adhesion receptor L1 as a Wnt/β-catenin target gene localized in cells at the invasive front of CRC tissue and showed that L1 expression in CRC cells confers enhanced motility and liver metastasis. 26399194 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE We further sequenced the key fragments of Apc, Ctnnb1, and Kras, because mutations of these genes in the humans are commonly found as the drivers of colorectal cancer. 25131582 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE The quantitative level of the β-catenin protein was significantly decreased in the CRC cell lysates, hence the expression level of c-Myc and cyclin D1 was significantly decreased following 2.5mM CaLa treatment. 26316447 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 AlteredExpression disease BEFREE In addition to co-expression of Wnt2 with Wnt/β-catenin target genes in CRC, knockdown or knockout of Wnt2 significantly downregulates Wnt/β-catenin target gene expression in CRC cells. 26484565 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 PosttranslationalModification disease BEFREE Three HDGF-binding elements in β-catenin promoter were found and specific for transcriptional activation of β-catenin in CRC cells. 26296979 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 AlteredExpression disease BEFREE Tumor nuclear CTNNB1 expression may be associated with higher mortality among older patients with colorectal cancer but not among younger patients. 26490308 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE The great majority of colorectal cancers have mutations in one of two genes involved in the Wnt signaling pathway: the adenomatous polyposis coli (APC) and β-catenin (CTNNB1) genes. 26439805 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE Additionally, depletion of LGR5 suppressed β-catenin nuclear translocation and blocked the activity of Wnt/β-catenin signaling as manifested in the reduced expression of c-myc and cyclin D, two Wnt/β-catenin targets in CRC cells. 25025569 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis. 24947187 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE Mutations in the APC or β-catenin genes are well-established initiators of colorectal cancer, yet modifiers that facilitate the survival and progression of nascent tumor cells are not well defined. 25113996 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 AlteredExpression disease BEFREE We identify Rad21 as a gatekeeper of LOH and a β-catenin target gene and provide evidence that Wnt pathway activation drives RAD21 expression in human CRC. 25464844 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease CTD_human Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. 25280562 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE Histo-pathological features and molecular changes [KRAS, BRAF and CTNNB1 genes mutations, microsatellite instability (MSI) phenotype, expression of mismatch repair (MMR) and mucin (MUC) 5AC proteins, mutation and expression analysis of TP53, MLH1 promoter hypermethylation analysis] were examined in a series of 51 unselected Tunisian CRC patients, 10 of them had a proven or probable hereditary disease, on the track of new tumoral markers for CRC susceptibility in Tunisian patients. 23983431 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations. 24317174 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE In the majority of microsatellite-stable colorectal cancers (CRCs), an initiating mutation occurs in the adenomatous polyposis coli (APC) or β-catenin gene, activating the β-catenin/TCF pathway. 24825889 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 AlteredExpression disease BEFREE Furthermore, the expression levels of hSETD1A are positively correlated with H3K4me3 enrichment at the promoters of Wnt/β-catenin target genes and the aberrant activation of these genes in human colorectal cancer. 24247718 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 AlteredExpression disease BEFREE SPDEF inhibited the expression of β-catenin-target genes in mouse colon tumors, and interacted with β-catenin to block its transcriptional activity in CRC cell lines, resulting in lower levels of cyclin D1 and c-MYC. 23376423 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE We selected and genotyped 10 tSNP to predict common variants across entire APC and CTNNB1 genes in 282 colorectal cancer patients. 23405266 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE Although the number of mutations in the APC and β-catenin genes in our CRC cases was very low, the study confirms the role of epigenetic gene silencing of the pivotal molecular gladiator, APC, of the Wnt pathway in the development of CRC in the Kashmiri population. 21807601 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE Notch is known to be a strong promoter of tumor initiation, but here we uncovered an unexpected suppressive role of Notch1 on WNT/β-catenin target genes involved in colorectal cancer. 22863622 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease BEFREE The paired-like homeodomain transcription factor 2 (PITX2) gene encodes a transcription factor controlled by the WNT/Dvl/CTNNB1 and Hedgehog/TGFB pathways in the pathogenesis of colorectal cancer (CRC). 21479692 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 Biomarker disease CTD_human CRC is initiated by mutations of the tumor suppressor gene, adenomatous polyposis coli (APC), or β-catenin gene. 21291235 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. 21521850 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.600 GeneticVariation disease BEFREE Alterations in the β-catenin gene are observed in 10-50% of the patients with colorectal cancer. 20717765 2011