Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE For this reason, it was suggested that immunohistochemistry against IDH1 R132H is sufficient to classify GBM as IDH wild-type in this age group. 31758617 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE This effect was not observed in patients with IDH1 mutant (IDH1Mut) GBM. 31746408 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE 67 patients aged 70 years or younger, operated between January 2013 and December 2015, with newly diagnosed IDH wild-type GBM and clinical follow-up were retrospectively investigated in this study. 31422371 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE U87 human GBM cells were treated with the IC50 concentration of various agents used in the treatment of GBM, including alkylating agents (temozolomide, carmustine, lomustine, procarbazine), inhibitor of topoisomerase I (irinotecan), vascular endothelial and epidermal growth factor receptor inhibitors (cediranib and erlotinib, respectively) anti-metabolite (5-fluorouracil), microtubule inhibitor (vincristine), and metabolic agents (dichloroacetate and IDH1 inhibitor ivosidenib). 30989436 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE Continuous administration of DS-1001b impaired tumor growth and decreased 2-HG levels in subcutaneous and intracranial xenograft models derived from a glioblastoma patient with IDH1 mutation. 31727689 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma. 30948344 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE In application to the glioblastoma dataset from The Cancer Genome Atlas, MHN proposed a novel interaction in line with consecutive biopsies: IDH1 mutations are early events that promote subsequent fixation of TP53 mutations. 31250881 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE Anaplastic astrocytoma, IDH-wildtype (AA-IDHwt) was the common molecular subgroup (52.8%), followed by diffuse astrocytoma, IDH-wildtype (DA-IDHwt) and AA, IDH-mutant (AA-IDHmt) (each 16.9%), DA-IDHmt (7.9%), glioblastoma (GBM)-IDHwt (3.3%) and GBM-IDHmt (2.2%). 31435963 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE IDH1 mutations are closely related to the development and progression of various human cancers, such as glioblastoma, sarcoma, and acute myeloid leukemia. 31836442 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE IDH-wild-type glioblastoma (GBM) is a disease with devastating prognosis. 31736002 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE Prognostic significance of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase-1 (IDH-1) mutation in glioblastoma multiforme patients: A single-center experience in the Middle East region. 31108342 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE The histomolecular profile appears to be different from that of supratentorial gliomas, with no IDH1/2 gene mutations and only 1 case with a classic profile of de novo glioblastoma. 29809131 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE Patients with IDH wild type anaplastic astrocytoma and glioblastoma had a significantly shorter median PFS (19.3 months vs. NR, p = 0.001) and median OS (43.5 months vs NR, p = 0.007) than those with IDH mutated grade III anaplastic astrocytoma and oligodendroglioma. 31371189 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE Consequently, we present a curated panel of 12 readily-usable, genetically-diverse, tumourigenic, patient-derived, low-passage, serum-free cell lines representing the spectrum of molecular subtypes of IDH-wildtype GBM along with their detailed phenotypic characterisation plus a bespoke set of lentiviral plasmids for bioluminescent/fluorescent labelling, gene expression and CRISPR/Cas9-mediated gene inactivation. 30894629 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma. 31591460 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE In both the GBM and LGG cohort study, most of the patients in the high-risk group had the IDH1 wild-type gene, and those in the low-risk group had IDH1 mutations. 30894197 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE Moreover, HLA-F was enriched in GBM and isocitrate dehydrogenase 1 wild-type (IDH1 wt) group and considered HLA-F as a mesenchymal subtype marker. 30755240 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE The autoradiographic study shows the entirely higher radioactivity of the U251/IDH1 R132H tumor tissue section than that of the U251/IDH1 Wild-type tumor. 31667733 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE We studied the association of immunohistochemical expression of hypoxia inducible factor-1 alpha (HIF-1α), telomerase reverse transcriptase (TERT), isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 with overall survival (OS) in glioblastoma patients uniformly treated by standard of care, with adequate follow-up. 31258744 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 AlteredExpression disease BEFREE Additionally, the concordance of low ALDOC and high non-mutated IDH1 expressions predicted a stronger poor prognosis in glioblastoma patients compared to each of above tests presented alone. 31450822 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE Recent DNA methylation analyses revealed a small group of IDH mutant diffuse gliomas exhibiting decreased DNA hypermethylation resulting in substantial unfavorable prognosis comparable to glioblastoma. 30937703 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 GeneticVariation disease BEFREE Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: a case report and review of current challenges in molecular diagnostics. 30738431 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE From Jan 2009 to Dec 2016, 161 patients with newly diagnosed IDH-wild type GB were treated with surgery and adjuvant concurrent chemoradiotherapy with the Stupp's regimen, and then genomic research proceeded with their surgical specimens. 30773189 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 Biomarker disease BEFREE We found that ADAMTSL4 was enriched in GBM (WHO grade IV), especially for those with IDH1/2 wild-type and MGMT unmethylated groups. 30728876 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.500 AlteredExpression disease BEFREE <b>Abbreviations</b>: AAAIR: Average Annual Age-Adjusted Incidence Rate; AI/AN: American Indian or Alaska Native; API: Asian or Pacific Islander; CBTRUS: Central Brain Tumor Registry of the United States; CUMC: Columbia University Medical Center; EOR: Extent of Resection; Exc: Excluded; GBM: Glioblastoma; GTR: Gross Total Resection; IDH-1: Isocitrate Dehydrogenase 1; MGMT: O6-Methylguanine DNA Methyltransferase; NCDB: National Cancer Database; OS: Overall Survival; O/U: Other/Unknown; PFS: Progression-Free Survival; SEER: Surveillance, Epidemiology, and End Results; S&W BTR: Scott & White Brain Tumor Registry; UCLA: University of California Los Angeles; UM: University of Miami. 31271539 2019