Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 AlteredExpression disease BEFREE MDM4 and USP2a, as well as the MDM4-USP2a complex, were more highly expressed in glioblastoma multiforme tissue samples from patients with good prognosis compared with patients with poor prognosis. 24445145 2014
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 AlteredExpression disease BEFREE This GBM chemosensitization was caused by a decrease in the expression and activity of the multiple drug associated protein 1 (Mrp1), the most important transporter conferring multiple drug resistance in these cells. 22833450 2013
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 Biomarker disease CTD_human In GBM cells, HDMX overexpression inhibits p53-mediated transcriptional activation of p21, releases cells from G0 to G1 phase, and enhances cellular proliferation. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 Biomarker disease CTD_human While in GBM cells treated with the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), HDMX appears to stabilize p53 and promote phosphorylation of the DNA double-stranded break repair protein H2AX, up-regulate the DNA repair gene VPX, stimulate DNA repair, and confer resistance to BCNU. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 Biomarker disease CTD_human In summary, HDMX exhibits bona fide oncogenic properties and offers a promising molecular target for GBM therapeutic intervention. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 Biomarker disease CTD_human Further genetic screening of 284 low- and high-grade gliomas revealed that HDMX amplifications occur solely in pediatric and adult GBMs and that they are mutually exclusive of TP53 mutations and MDM2 amplifications. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 Biomarker disease BEFREE In summary, HDMX exhibits bona fide oncogenic properties and offers a promising molecular target for GBM therapeutic intervention. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 Biomarker disease CTD_human Here, we demonstrate that HDMX regulates p53 to promote GBM growth and attenuates tumor response to chemotherapy. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 AlteredExpression disease BEFREE Furthermore, our results that exhibit protein expression of MRP1 and MRP3 and gene expression of MRP4 and MRP5 in these 2 glioblastoma cell lines suggest new mechanisms that could lead to a MDR phenotype of tumour cells in patients with glioblastoma multiforme. 11857404 2002
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.540 GenomicAlterations disease CGI
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.520 GeneticVariation disease UNIPROT IDH2 mutation in gliomas including novel mutation. 25495392 2016
Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
0.520 GeneticVariation disease BEFREE Presence of distinct clusters and an H3F3A mutation-specific methylome indicate existence of epigenetic subgroups within pediatric GBM. 24997139 2015
Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
0.520 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
0.520 GeneticVariation disease BEFREE Screening of a large cohort of gliomas of various grades and histologies (n = 784) showed H3F3A mutations to be specific to GBM and highly prevalent in children and young adults. 22286061 2012
Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
0.520 Biomarker disease CTD_human Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. 22286216 2012
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.520 GeneticVariation disease BEFREE Some findings, such as that of IDH mutation in low-grade gliomas and secondary glioblastoma (GBM), fit well into established notions of different routes of gliomagenesis. 21465149 2011
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.520 GeneticVariation disease BEFREE Subsequent studies have confirmed recurrent IDH1 and IDH2 mutations in up to 70% of low-grade glioma and secondary GBM, as well as in 10% of acute myeloid leukemia (AML) cases. 20692206 2010
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.520 GeneticVariation disease UNIPROT IDH1 and IDH2 mutations in gliomas. 19228619 2009
Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
0.520 GeneticVariation disease UNIPROT
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.520 CausalMutation disease CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme. 28583430 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Next generation sequencing and molecular imaging identify EGFR mutation and amplification in a glioblastoma multiforme patient treated with an EGFR inhibitor: a case report. 28611289 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Predicting epidermal growth factor receptor gene amplification status in glioblastoma multiforme by quantitative enhancement and necrosis features deriving from conventional magnetic resonance imaging. 29794775 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Intronic miRNA-641 controls its host Gene's pathway PI3K/AKT and this relationship is dysfunctional in glioblastoma multiforme. 28576488 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme. 28934307 2017