Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 Biomarker phenotype BEFREE We investigated SERPINC1 defects in Japanese patients with congenital AT deficiency who developed venous thromboembolism or had a family history of deep vein thrombosis. 31030036 2019
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE Mutations in SERPINC1 and PROC lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). 28861852 2018
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE Inherited quantitative (type I) or qualitative (type II) antithrombin deficiency (ATD) due to mutations in the SERPINC1 gene is a well-known risk factor for venous thromboembolism. 28300866 2017
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE We performed a meta-analysis with trial sequential analysis to investigate the associations between the endothelial cell-activated protein C receptor (EPCR) rs9574, F11 rs2289252, F11 rs2036914, FGG rs2066865, FGG rs1049636, CYP4V2 rs13146272, SERPINC1 rs2227589, and GP6 rs1613662 polymorphisms with the risk of VTE. 28353616 2017
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE This study demonstrated that different types of SERPINC1 mutations may play different roles in the development of VTE and should be considered in the prevention of VTE. 27863268 2016
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. 23150947 2013
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE These defects are responsible for only a moderate increase of venous thromboembolism (VTE) risk compared with strong thrombophilias (antithrombin III, protein C and protein S deficiencies and homozygous forms of factor V Leiden and G20210A prothrombin mutation). 23026651 2012
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 Biomarker phenotype BEFREE After adjustment for other inherited causes of thrombophilia (deficiency of antithrombin III, protein C or S, factor V Leiden) the overall risk for VTE associated with the prothrombin polymorphism was 3.4 times higher than in the controls (95% CI, 2.0 to 5.8). 12551828 2003
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 GeneticVariation phenotype BEFREE The inherited thrombophilias--deficiencies of protein C, protein S, and antithrombin III--and the prothrombotic polymorphisms factor V G1691A and factor II G20210A predispose patients toward venous thromboembolism (VTE). 10073951 1999
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 Biomarker phenotype BEFREE Inherited deficiency of antithrombin III is a well recognised risk factor for the early development of venous thromboembolism. 7937056 1994
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 Biomarker phenotype BEFREE The major clinical manifestations of ATIII deficiency are young age at onset, idiopathic thrombosis, family history, and recurrent venous thromboembolism. 2679068 1989
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 Biomarker phenotype BEFREE Four members of an Italian family (two with histories of venous thromboembolism) had a qualitative defect of antithrombin III reflected by normal antigen concentrations and half-normal antithrombin activity with or without heparin. 3563966 1986
Entrez Id: 462
Gene Symbol: SERPINC1
SERPINC1
0.400 Biomarker phenotype CTD_human The effect of chlorotrianisene as postpartum lactation suppression on blood coagulation factors. 453287 1979