Gene: FLT3 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Dynamics of clonal evolution in myelodysplastic syndromes. 27992414 2017
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 GeneticVariation disease BEFREE Trisomy 8 alone was associated with older age (median age 10.1 years), FAB M2 (33%), and FLT3-ITD mutations (58%). 27153159 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. 27099147 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. 24526162 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD. 25053825 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: its correlation with FLT3. 23906301 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. 23036488 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation. 22409268 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo. 21928377 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 SomaticCausalMutation disease ORPHANET Molecular and clinicopathologic characterization of AML with isolated trisomy 4. 22338050 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. 21482694 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. 21441929 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Micro-RNAs and copy number changes: new levels of gene regulation in acute myeloid leukemia. 19822134 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 GeneticVariation disease BEFREE Prevalence of FLT3-ITD is as high as 70% among patients with t(6;9) AML, and patients with t(6;9) AML and FLT3-ITD mutations usually have higher white blood cell counts, higher bone marrow blasts, and significantly lower rates of complete remission. t(6;9) is most commonly associated with AML-FAB-M2 and is considered by some researchers to be a separate disease entity because of its distinct clinical and morphologic features and poor prognostic implication. 18976025 2008
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice. 17184839 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication. 17050201 2006