Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Elevated methylation of cyclin dependent kinase inhibitor 2B contributes to the risk of coronary heart disease in women. 30651784 2019
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE We investigate the association of 9p21.3 two haplotype blocks lead variants (rs10757278 and rs518394) with first-ever non-fatal myocardial infarction (MI) in CAD patients and their association with CDKN2B mRNA expression in peripheral blood mononuclear cells 6 months after the event. 31386834 2019
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease. 29894795 2018
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE In this study, we verify the association between the rs1333049 single nucleotide polymorphism (9p21.3) within CDKN2A-CDKN2B and coronary artery disease (CAD) in an Italian population. 28639227 2017
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease GWASDB Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 AlteredExpression disease BEFREE Interferon-γ activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype. 23199516 2013
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Our thorough genomic characterization of 9p21.3 suggests common variants likely account for observed disease associations and provides further support for the hypothesis that complex regulatory variation affecting ANRIL and CDKN2B gene expression may contribute to increased risk for clinically apparent and subclinical coronary artery disease and aortic disease. 23315372 2013
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Recently, genome-wide association studies on coronary artery disease (CAD) identified a series of associated single-nucleotide polymorphisms (SNPs) in an intergenic region of chromosome 9p21.3, near the CDKN2A and CDKN2B genes. 23086272 2013
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 Biomarker disease BEFREE In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal. 23104008 2012
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Genome-wide association studies have identified a coronary artery disease (CAD) risk locus in a non-coding region at 9p21.3, the nearest genes being CDKN2A and CDKN2B. 22768093 2012
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 AlteredExpression disease BEFREE The results of this study indicate that the 9p21 variation has an impact on CDKN2A and CDKN2B expression in VSMCs and influences VMSC proliferation, which likely represents an important mechanism for the association between this genetic locus and susceptibility to CAD. 22706276 2012
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 Biomarker disease CTD_human In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal. 23104008 2012
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 PosttranslationalModification disease BEFREE Further investigation determined that p15(INK4b) hypermethylation prevalently emerged in lymphocytes of CAD patients (p = 0.013). 23091611 2012
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE This is the first report of a CAD association signal in a population of African ancestry with a common variant within the CDKN2B gene, independent from previous findings in European and East Asian ancestry populations. 21270820 2011
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 Biomarker disease BEFREE Cardiac expression of two genes near the non-coding interval, Cdkn2a and Cdkn2b, is severely reduced in chr4(Delta70kb/Delta70kb) mice, indicating that distant-acting gene regulatory functions are located in the non-coding CAD risk interval. 20173736 2010
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm. 19343170 2009
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.500 GeneticVariation disease BEFREE Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes. 18340101 2008