Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 Biomarker disease BEFREE This manuscript mainly reviewed existing evidences suggesting the opposite role of apoC3 and apoA5 in lipid metabolism and CAD risk, and discussed the potential correlation between these two apolipoproteins. 31836003 2019
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls. 28705542 2019
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE The present study therefore aimed to investigate the consequences of the genetic variant c.553G > T (rs2075291) in apolipoprotein A5 gene to determination of triglycerides levels in CAD patients receiving, atorvastatin, lipid lowering drug. 30606120 2019
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE The polymorphic alleles of APOA5 (rs2266788 (C), rs3135506 (G)), LPA (rs10455872 (A), rs3798220 (G)) and 9p21.3 (rs1333049 (C), rs2383207(A)) have been reported in association with susceptibility of coronary artery disease (CAD) from genome wide association studies. 29309886 2018
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Hyperlipidemia is a risk factor of arteriosclerosis, stroke, and other coronary heart disease, which has been shown to correlate with single nucleotide polymorphisms of genes essential for lipid metabolism, such as lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5). 29425239 2018
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Effects of polymorphisms in APOA5 on the plasma levels of triglycerides and risk of coronary heart disease in Jilin, northeast China: a case-control study. 29866721 2018
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE These results suggest that APOA5 variation regulates TG and HDL levels, thus displaying a causal role in the development of CAD. 30024021 2018
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE The objective of the current study was to investigate the effect of four such single nucleotide polymorphism (SNPs) in the genes for Lipoprotein Lipase (LPL) (rs328, rs1801177), Apolipoprotein A5 (APOA5) (rs66279) and Cholesteryl ester transfer protein (CETP) (rs708272) on HDL-C and TG levels and to examine the association of these SNPs with CAD risk. 28143480 2017
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease GWASCAT Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. 29263402 2017
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE We identified a missense SNP (rs2075291, G > T, G185C) in APOA5 for CAD that reached robust genome-wide significance (Meta P = 7.09 × 10<sup>-10</sup>, OR = 1.636). 29263402 2017
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 Biomarker disease BEFREE The independent variants at PCSK9, HMGCR, LPA, APOA5 and LDLR were also associated with increased risk of coronary artery disease in the expected direction. 27516387 2016
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Interaction of variants that belong to regulatory genes BUD13 and ZPR1 with APOA5-APOA4 intergenic variants is also observed to significantly increase the risk towards CAD. 27257688 2016
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women. 27716220 2016
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE In conclusion, our meta-analysis provides substantial evidence that the APOA5 -1131T/C polymorphism might contribute to CAD development in the Chinese population. 26505382 2015
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis. 26309253 2015
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. 26387083 2015
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease. 26782469 2015
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 Biomarker disease BEFREE Genetic variants in APOA5/A4/C3/A1 gene cluster play an important role in the regulation of plasma triglyceride levels by an increased APOA5 concentration and contribute to the severity of CAD. 25034063 2014
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE The Apolipoprotein A5 (APO A5) -1131T/C, fibrinogen β (FgB) -455G/A, -148C/T, and cholesteryl ester transfer protein (CETP) TaqIB gene polymorphisms have been indicated to be associated with the coronary artery disease (CAD) risk, but the individual study results are still inconsistent. 23129316 2013
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis. 23970179 2013
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 Biomarker disease CTD_human Common variants associated with plasma triglycerides and risk for coronary artery disease. 24097064 2013
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE CAD association was replicated and/or verified for 4 loci: SORT1 rs611917 (p=1.7 × 10(-8)), APOA5 rs662799 (p=0.0014), LDLR rs1433099 (p=2.1 × 10(-7)), and APOE rs7412 (p=6.1 × 10(-13)). 23050023 2012
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE APOA5 p.S19W was more frequent in patients with CAD (CAD, 14.4%; no CAD, 7.8%; P = 0.021); and in addition, all homozygous subjects (n = 5) for APOA5 p.S19W had CAD. 22914599 2012
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 GeneticVariation disease BEFREE Our findings support the view that -1131T/C polymorphism of the APOA5 gene is associated with CAD and the C allele might be a genetic risk factor that increases susceptibility to CAD. 21143013 2011