Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 AlteredExpression disease BEFREE There were no differences in expression of estrogen receptor (ER) between three regions of adipose tissue both in men with CAD with and without SHF. 30193537 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Correlation between polymorphisms in the estrogen receptor α gene and coronary heart disease: A meta-analysis. 27706721 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility. 24599688 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Meta-analysis of the association of the rs2234693 and rs9340799 polymorphisms of estrogen receptor alpha gene with coronary heart disease risk in Chinese Han population. 23471591 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 Biomarker disease BEFREE There was significant enrichment of ESR1 binding present in multiple datasets near genomic regions associated with breast cancer (7.45-fold, p = 0.001), height (2.45-fold, p = 0.002), multiple sclerosis (5.97-fold, p < 0.0002) and prostate cancer (4.47-fold, p = 0.0008), and suggestive evidence of ESR1 enrichment for regions associated with coronary artery disease, ovarian cancer, Parkinson's disease, polycystic ovarian syndrome and testicular cancer. 24171864 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population. 22284250 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Despite the widespread expression of ERα in vascular tissues, we found no evidence for involvement of common or low-frequency genetic variation throughout the ESR1 gene in modifying risk of CAD, either in the general population or as a function of sex. 21984528 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 Biomarker disease BEFREE To test whether estrogen receptor polymorphisms modify the effects of postmenopausal hormone therapy on biomarkers and on risk of coronary heart disease events, stroke, or venous thromboembolism. 21106950 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 Biomarker disease CTD_human Modulation of gene expression by Polyalthia longifolia in postmenopausal women with coronary artery disease: an in vitro study. 20559769 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE ESR1 genetic variants, haplotypes and the risk of coronary heart disease and ischemic stroke in the Finnish population: a prospective follow-up study. 20153472 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography. 19318036 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE After adjusting for CAD and age, no impacts of ESR1 PvuII and XbaI polymorphisms were found on lipid profile, lipoprotein (a) level, and quantitative CRP either in total population or in subgroups stratified by gender. 19446283 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE We have previously reported significant association of ER alpha gene (ESR1) variants with more severe coronary artery disease (CAD) in postmenopausal women. 19938352 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism. 19008156 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Qualitative assessment of previous evidence and an updated meta-analysis confirms lack of association between the ESR1 rs2234693 (PvuII) variant and coronary heart disease in men and women. 19608186 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE There have been studies examining the association between coronary artery disease and the estrogen receptor alpha (ESR1) gene. 18360040 2008
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population. 18582450 2008
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease LHGDN The relationship of the ESR1 gene polymorphisms with the presence of coronary artery disease determined by coronary angiography. 18294052 2007
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 Biomarker disease BEFREE Associations of CAD with estrogen receptor alpha (ER alpha) polymorphisms, which may influence sensitivity to estrogen, have been reported for men; the data concerning women are not conclusive. 17389465 2007
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE The estrogen receptor-1 (ESR1, c.454-397T>C) CC variant genotype is associated with the severity of coronary artery disease (CAD) and an increased risk of myocardial infarction in men. 17558892 2007
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE The relationship of the ESR1 gene polymorphisms with the presence of coronary artery disease determined by coronary angiography. 18294052 2007
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population. 16612467 2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Effect of hormone replacement therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha IVS1-397 C/C genotype and established coronary artery disease. 16612068 2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE Mutation in the ESR1 (PvuII) was more prevalent in the controls (18 vs. 11%; p=0.062) than in CAD patients, and the mutation identified by the XbaI enzyme in the same receptor was associated with reduced apolipoprotein B levels and low body mass index. 16099331 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.400 GeneticVariation disease BEFREE This study seeks to investigate the association between the ESR1 haplotype created by the c.454-397 T>C and c.454-351 A>G polymorphisms, the length of the (TA)n repeats, and the angiographic extent of CAD. 16159931 2005