| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | The G6230A CTLA4 variant does not confer susceptibility to LADA in Sardinian patients even when associated with AITD. | 25695113 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis. | 25005490 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or <20 years of age (T1D(<20y); n = 158), and type 2 diabetes. | 20805278 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations. | 19332045 | 2009 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The current study confirms the involvement of CTLA-4 gene promoter polymorphisms in the susceptibility of LADA and extends our previous findings of associations with other CTLA-4 polymorphisms. | 19735686 | 2009 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Additionally, there was an increased association between LADA and CTLA-4 diabetes-susceptibility genotypes and decreased association with INS VNTR and high-risk HLA-DQB1 alleles, compared with T1D. | 17257313 | 2007 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Between SPIDDM and LADA some differences are reported in terms of some genetic predispositions including HLA class II and class I genes, vitamin D receptor gene, and CTLA4 genes. | 17130533 | 2006 | ||||
|
0.080 | Biomarker | disease | BEFREE | The results of our study show that LADA is positively associated with the CTLA-4 A/G genotype, similarly to T1DM, thus providing further supporting evidence of the autoimmune origin of this form of diabetes mellitus of the adult. | 12021137 | 2002 |