Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 Biomarker disease BEFREE The combination of overweight and high-risk genotypes of HLA, TCF7L2, and FTO was associated with pooled relative risk (RRpooled) of 7.59 (95% CI, 5.27 to 10.93), 2.65 (95% CI, 1.97 to 3.56), and 2.21 (95% CI, 1.60 to 3.07), respectively, for LADA, compared with normal-weight individuals with low/intermediate genetic risk. 31125083 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA). 30456822 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE Variants in the ZMIZ1 (rs12571751, p = 4.1 × 10(-5)) and TCF7L2 (rs7903146, p = 5.8 × 10(-4)) loci were strongly associated with LADA. 24906951 2014
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE The meta-analysis yielded a significant effect of TCF7L2 T allele (OR 1.28; p < 0.0001) on LADA risk without heterogeneity among Europeans. 22109281 2012
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE TCF7L2 common genetic variants of susceptibility are associated only with low GADA antibody titre in LADA patients. 20546291 2010
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE We observed increased frequencies of the TT genotype of the rs7903146 polymorphism in the TCF7L2 gene in LADA patients compared to controls (15 vs. 6%, P = 0.03). 19533015 2010
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE However, and somewhat at odds with current thinking, TCF7L2, the most strongly associated gene with T2D to date, is strongly associated with LADA, a disorder considered by the World Health Organization to be a slowly progressing form of T1D. 20007922 2010
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.080 GeneticVariation disease BEFREE Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 x 10(-7)), compared with control subjects (44.8%) and type 1 diabetic subjects (43.3%). 18310307 2008