Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 AlteredExpression disease BEFREE CONCLUSIONS MTF can enhance the potential of RGF and inhibit the recurrence and metastasis of HCC after postoperative liver section by regulating the levels of TIP30 and HIF-2α. 29654226 2018
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat interactive protein 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma. 30402840 2018
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE ROC analysis revealed an optimal cut-off point at 7.27 ng/ml HTATIP2/TIP30 for separating the HCC from the control groups. 28599422 2017
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Clinically, our data revealed that TIP30 expression significantly correlated with SREBP1 in patients with HCC and that a combination of TIP30 and SREBP1 is a powerful predictor of HCC prognosis. 28604762 2017
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Thioredoxin, a prometastasis factor, is negatively regulated by TIP30 and plays an essential role during the process of HCC metastasis. 26752068 2016
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE To further explore the correlation between TIP30 and HBV infection in HCC, HBV(+) hepatoblastoma cell-line HepG2 2.2.15 and HCC cell-line Hep3B were used. 27418384 2016
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Taken together, our results suggest a novel and critical role of TIP30 involved in HCC progression and aggressiveness. 24681951 2015
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Moreover, TIP30(-/-) mice spontaneously develop hepatocellular carcinoma and other tumors at a higher incidence than that of wild-type mice. 26629947 2014
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 AlteredExpression disease BEFREE Aspirin did not inhibit the proliferation of HCC cells, but it decreased the invasiveness of HCC with lower expression of HTATIP2 and increased expression of a set of markers, indicating a mesenchymal-to-epithelial transition in tumor cells. 23741443 2013
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 AlteredExpression disease LHGDN Here, we show that TIP30, also called CC3, regulates p53 mRNA stability and induces apoptosis by sensing of intracellular oxidative stress in human hepatocellular carcinoma (HCC) cells. 18519672 2008
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells. 17997990 2008
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 PosttranslationalModification disease BEFREE Moreover, analyses of Tip30 promoter methylation status in 59 paired HCC tissues showed that 47% of the cases were hypermethylated. 19010857 2008
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 AlteredExpression disease BEFREE Moreover, expression of TIP30 was inversely associated with OPN expression in HCC tissue samples as detected by immunohistochemistry assay. 18537194 2008
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Here, we show that TIP30, also called CC3, regulates p53 mRNA stability and induces apoptosis by sensing of intracellular oxidative stress in human hepatocellular carcinoma (HCC) cells. 18519672 2008
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 GeneticVariation disease BEFREE Taken together, our data indicate that somatic mutations in the TIP30 gene may abolish its native tumor-suppressor activity and gain oncogenic activities partially through up-regulation of N-cadherin, thereby potentiating the pathogenesis of HCC in patients. 17440068 2007
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 AlteredExpression disease BEFREE Overexpression of TIP30 might be a promising candidate as a treatment for HCC that would increase sensitivity to chemotherapeutic drugs. 16799960 2006
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Therapeutic disease CTD_human Overexpression of TIP30 might be a promising candidate as a treatment for HCC that would increase sensitivity to chemotherapeutic drugs. 16799960 2006
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 Biomarker disease BEFREE Ad-TIP30 carrying exogenous TIP30-anti-tumor genes may be regarded as a potential candidate for the treatment of hepatocellular carcinoma. 15633220 2005
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 AlteredExpression disease BEFREE Furthermore, immunohistochemical analysis indicates that reduced TIP30 expression is associated with 33% of human hepatocellular carcinomas. 14695192 2003
Entrez Id: 10553
Gene Symbol: HTATIP2
HTATIP2
0.600 GeneticVariation disease UNIPROT