Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Aberrant activation of the oncogenic phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. 31663122 2020
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Tumor cells from these mice demonstrated high activity of the AKT/ mammalian target of rapamycin (mTOR) and Ras/ Mitogen-activated protein kinase (MAPK) signaling cascades, two pathways frequently co-induced in human HCC. 31277283 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Through protein and histological analyzes we observed activation of these pathways in human HCC, suggesting that targeting both mTOR and Src may be a novel approach for the treatment of HCC. 30794695 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Although the review focuses on the mTOR pathway involved in HCC, more comprehensive discussions (eg, developing a rational design for future trials targeting the mTOR pathway) are also applicable to other tumors. 30951815 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 AlteredExpression disease BEFREE <b>Abbreviations:</b> Atg5: autophgy related 5; DKO: double-knockout; HCC: hepatocellular carcinoma; INS: insulin; INSR: insulin receptor; KEAP1: kelch-like ECH-associated protein 1; KO: knockout; MTOR: mechanistic target of rapamycin kinase; NFE2L2: nuclear factor, erythroid 2 like 2; raptor: regulatory associated protein of MTOR, complex 1; SQSTM1: sequestosome 1: tsc1: TSC complex subunit 1. 31216956 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Suppression of LKB1 or promotion of AMP by metformin also abrogated the hyperproliferative phenotype caused by SIRT4 loss, which further confirmed that the LKB1/AMPKα/mTOR axis is required in SIRT4-deficiency-promoted HCC tumorigenesis. 30552782 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE PI3K/mTOR inhibition prevented moderate heat stress-induced global effects on HCC molecular signaling and cellular function, including decreased cell survival, growth, and proliferation (Z-score, -0.3 to -3.2; <i>P</i> < .001) and increased apoptosis and cell death (Z-score, 0.4-1.1; <i>P</i> < .001).ConclusionModerate heat stress induces PI3K/mTOR/AKT-dependent global effects on hepatocellular carcinoma (HCC) cell survival, function, and death. 31335281 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 AlteredExpression disease BEFREE MAP3K7 expression was positively correlated with mTOR expression in tumors of patients with HCC. 31214512 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR). 31427562 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 AlteredExpression disease BEFREE MTOR expression was increased in patients with multinodular HCC (tumoral <i>p</i> = 0.01; peritumoral <i>p</i> = 0.001). 30650598 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Antitumor effect of sorafenib and mammalian target of rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence. 29710388 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Immunohistochemical analysis showed that mTOR was characteristically phosphorylated in liver tumors of TSOD mice and HCCs from metabolic syndrome cases in humans. 30469530 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 AlteredExpression disease BEFREE Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma. 29220539 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE The mammalian target of rapamycin, mTOR, has become an attractive cancer therapeutic target in HCC. 30056112 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Indeed, BC suppresses autophagy induced by an mTORC1 inhibitor and synergizes cell death caused by mTORC1 inhibition in TIC and Huh7 spheroid formation and in the patient-derived xenograft model of HCC. 29729190 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. 29037858 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Activation of phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway was involved in the development of HCC and acquired resistance to sorafenib. 29360358 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression. 28065789 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 GeneticVariation disease BEFREE We identified and confirmed multiple mTOR components as recurrently mutated in HBV-associated HCCs. 27974549 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Anthracimycin is a novel mTOR inhibitor capable of suppressing the proliferation of CSCs and non-CSCs equally well in HCC, and it is suggested that anthracimycin could be effective in the eradication of HCC associated with mTOR-signaling activation. 28668827 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE We have shown previously that rapamycin, the canonical inhibitor of the mechanistic target of rapamycin (mTOR) complex 1, markedly inhibits the growth of focal lesions in the resistant hepatocyte (Solt-Farber) model of hepatocellular carcinoma (HCC) in the rat. 28199961 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE These results suggest that mTOR-STAT3-HK2 pathway is involved in the glycolysis of HCC cells and STAT3 may regulate HCC glycolysis through HK2 pathway, providing potential multiple therapeutic targets through intervention of glycolysis for the treatment of HCC. 28445971 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 AlteredExpression disease BEFREE Over-activation of mammalian target of rapamycin (mTOR) is important for HCC tumorigenesis and progression. 28334043 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 Biomarker disease BEFREE Dysregulation of mammalian target of rapamycin (mTOR) in hepatocellular carcinoma (HCC) represents a valuable treatment target. 28366631 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.400 AlteredExpression disease BEFREE Metformin inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which is frequently upregulated in hepatocellular carcinoma (HCC). 28881582 2017