Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE RNAscope for GPC3 and GS panel was highly specific and sensitive for the pathological identification of dysplastic nodules, early stages of HCCs, and would differentiate them from HCCs and metastatic tumors compared with IHC. 31832976 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE It also was demonstrated that GPC3CAR-T cells displayed potent cytotoxicity against GPC3-positive HCC cell lines in vitro by using real-time cell analyser (RTCA) system and the JuLI™ Stage Cell History Recorder. 31522780 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE In this work, we confirm that RAF1 acts as an oncogene in HCC and further demonstrate that miR-4510 acts as a strong tumour suppressor in the liver by targeting many proto-oncogenes, including GPC3 and RAF1, and subsequently controlling key biological and signalling pathways among which Wnt and RAS/RAF/MEK/ERK signals. 31612616 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 AlteredExpression disease BEFREE Arginase-1 and glypican-3 gene expression studies confirmed that the tumor samples used in our study originate from HCC livers but not non-hepatocellular tumors. mRNA and protein expression of PPM1A and CYP3A4 was found to be significantly repressed in the tumor liver tissues compared to the matched non-tumor liver tissues. 31792727 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 AlteredExpression disease BEFREE We constructed XCL1-GPC3 fusion molecules as a liver cancer vaccine by linking the XCL1 chemokine to glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma (HCC). 31666238 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE The plasma concentration of GPC3 could be a predictive marker of tumoral GPC3 expression in patients with HCV-related HCC, suggesting a useful biomarker for immunotherapies targeting GPC3, although larger-scale validations are needed. 31774932 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE All studies provided the sensitivity and specificity of GPC3 and the alpha-fetoprotein (AFP) in the HCC and LC diagnosis. 31113610 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 AlteredExpression disease BEFREE The purpose of this study was to develop a target-specific radiofluorinated peptide for positron emission tomography (PET) imaging of GPC3 expression in hepatocellular carcinoma. 31044341 2020
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Although the precise function of GPC3 remains unclear, it has been strongly suggested that it is related to the malignant transformation of HCC. 31024850 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 AlteredExpression disease BEFREE Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3), which is expressed in hepatocellular carcinoma (HCC), was tested in a randomized phase II trial in advanced HCC patients who had failed prior systemic therapy. 30922327 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE GPC3 has been linked to hepatocellular carcinoma and a few other cancers, however, the mechanistic role of GPC3 in cancer development remains elusive. 31428581 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE To investigate the role of glypican-3 (GPC3) in cobalt chloride (CoCl<sub>2</sub>)-induced cell apoptosis in hepatocellular carcinoma. 31824173 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3-Targeted Chimeric Antigen Receptor-Engineered T Cells in Hepatocellular Carcinoma. 31142602 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Treatment of hepatocellular carcinomas (HCC) using our glypican-3 (GPC3)-targeting human nanobody (HN3) immunotoxins causes potent tumor regression by blocking protein synthesis and down-regulating the Wnt signaling pathway. 31520528 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE To improve specificity, we developed a probe that specifically targets hepatocellular carcinoma by recognizing the biomarker GPC3 on the hepatocellular carcinoma cell membrane. 30776888 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 AlteredExpression disease BEFREE The positive rates of CK7 and CK19 expression were higher in CHCC group than in HCC group (both P < .001), while the positive rates of Glypican-3 and Hepatocyte expression were higher in CHCC group than in ICC group (both P < .001). 31567946 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Thus, this study applied two of the most commonly used mouse models for CAR T cell research and demonstrated the clinical potential of combining sorafenib with GPC3-targeted CAR T cells against HCC. 31078430 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE T cells expressing M28z10 or G28z10 showed enhanced and prolonged effector function against MSLN+ lung cancer or GPC3hepatocellular carcinoma cell lines in culture and secreted elevated levels of cytokines, including IL-2, IFN-γ, granzyme B, and GM-CSF. 30546945 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 AlteredExpression disease BEFREE Curcumin suppressed HCC tumor growth through down-regulating GPC3/wnt/β-catenin signaling pathway, which was partially mediated by activation of autophagy. 30001951 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE In our perception, the method is of great clinical significance as combination of GPC-3 and AFP increases the sensitivity of detection of HCC. 30904972 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Associated measurement of fucosylated levels of AFP, DCP, and GPC3 for early diagnosis in hepatocellular carcinoma. 30854929 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE This review introduces the results of recent clinical trials targeting GPC3 in HCC and summarizes the latest knowledge regarding the role of GPC3 in HCC progression and clinical application targeting GPC3. 31510063 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma. 31536939 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE Our study provided new insights of the anticarcinogenic effects of EGCG and metformin on HCC through their effects on glypican-3 and lncRNA-AF085935. 30710234 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.600 Biomarker disease BEFREE The current findings showed the significance of recognizing distinct GPC3 staining patterns, i.e., diffuse and canalicular, which may reflect different carcinogenetic mechanisms and indicate the level of malignancy of HCC. 30729617 2019