Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.700 AlteredExpression disease BEFREE Integration analysis of aCGH and expression data showed that MDM4 and BCL2L1 were significantly upregulated in HCCs with gene gain, while APC and FBXW7 were significantly downregulated in HCCs with gene loss. 31612394 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.700 PosttranslationalModification disease BEFREE APC methylation was the highest in HCC group (70%). 29865038 2018
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE Together, our findings unravel the LSD1/Prickle1/APC/β-catenin signaling axis as a novel molecular circuit regulating the stemness and chemoresistance of hepatic Lgr5(+) CICs and provide potential targets to improve chemotherapeutic efficacies against HCC. 25893304 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.700 PosttranslationalModification disease BEFREE By using methylation sensitive restriction enzyme-quantitative PCR, hypermethylation of APC was detected in HCC with different risk factors, whereas SFRP1 and SFRP5 were not hypermethylated in any of the HCC etiologies, which indicates that the mutation of APC and AXIN1, together with the methylation of APC could take part in the overactivation of Wnt signaling. 26034368 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE Considering the strong association between the ratio of the methylated to unmethylated APC sequences in serum and the presence of portal vein thrombosis, methylation status of APC sequences could be a promising marker for improving HCC management. 23428864 2013
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE These results suggested that Emi1 participates in HCC cell proliferation and that progression is controlled by APC/C inhibition, which stabilized Skp2 and enabled p27(kip1) degradation. 22995332 2013
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE In particular, APC and YWHAZ were highlighted as two most remarkable genes in the network modules, and their dynamic interaction partnership was resolved in HCC development. 24564909 2013
Entrez Id: 324
Gene Symbol: APC
APC
0.700 AlteredExpression disease BEFREE Epigenetic inactivation of tumor suppressor genes like RASSF1A or APC by overexpression of DNA methyltransferases (DNMTs) has been shown to be common in HCC and to be linked to the overall prognosis of patients. 22943463 2012
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE To determine the effect of the DNA strand on the specificity of the methylated APC gene as a biomarker for HCC detection, quantitative methylation-specific PCR assays for sense and antisense strand DNA were developed and performed on DNA isolated from HCC (n = 58), matched adjacent non-HCC (n = 58), cirrhosis (n = 41), and hepatitis (n = 39). 22073196 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE In contrast to common HCC the APC and CDH1 (E-cadherin) genes were found devoid of any DNA methylation in FLC, whereas the GSTπ1 gene showed comparable DNA methylation in tumor and surrounding tissue at a moderate level. 21060828 2010
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE We evaluated the diagnostic applicability of this approach by examining the methylation status of two tumor suppressor genes, RASSF1A and APC, in 10 paired hepatocellular carcinoma (HCC) and the corresponding non-tumor liver tissues. 19332050 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.700 PosttranslationalModification disease BEFREE Promoter methylation of the APC gene seems to be of significance in hepatocarcinogenesis and results in reduced protein expression in HCC. 17973119 2008
Entrez Id: 324
Gene Symbol: APC
APC
0.700 PosttranslationalModification disease BEFREE The hypermethylation frequency of GSTP1 and RASSF1A showed significant difference between HCCs and liver cirrhosis with or without HBV infection (P<0.05), but differences of the hypermethylation status of APC, E-cadherin, and P16 were not statistically significant. 18691570 2008
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE DNA promoter methylation frequencies in HCC and matching non-malignant cirrhotic liver, respectively, were as follows: p16(INK4a) (76% vs. 24%), GSTP1 (53% vs. 32%), MGMT (6 vs. 12%), DAP-K (68 vs. 100%) and APC (100 vs. 100%). 18351580 2008
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE Mutations of beta-catenin, APC, and axins are important but not frequent enough to be accountable for the accumulation of beta-catenin in human hepatocellular carcinoma (HCC). 17030191 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE In conclusion, combined with an immunohistochemical analysis of the beta-catenin protein, this case provides the first evidence that genetic inactivation of the APC gene can play a significant role in the progression of sporadic HCC, probably by activating the Wnt/beta-catenin pathway. 16897741 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. 15067328 2004
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE The peptidyl-proplyl-isomerase, PIN1, upregulates beta-catenin by inhibiting its interaction with APC. beta-catenin accumulation occurs in about 70% of hepatocellular carcinoma (HCC), of which only 20% are due to beta-catenin mutations. 15064734 2004
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE The most frequently methylated TSGs in HCC were: SOCS-1 (65%), GSTP (54%), APC (53%), E-cadherin (49%), and p15 (49%). 12937151 2003
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE The genes frequently methylated in HCC were APC (81.7%), GSTP1 (76.7%), RASSF1A (66.7%), p16 (48.3%), COX-2 (35%), and E-cadherin (33.3%). 14507645 2003
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE In our study, we screened HCCs resulting from HCV infection (51 cases), HBV infection (26 cases) or excess alcohol intake (23 cases) for alterations in genes involved in the RB1 pathway (p16(INK4a), p15(INK4b), RB1, CDK4 and cyclin D1), the p53 pathway (p53, p14(ARF) and MDM2) and the Wnt pathway (beta-catenin, APC). 12845670 2003
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE To the authors' knowledge, this study provides the first evidence that biallelic inactivation of the APC gene may contribute to the development of HCC in patients with FAP. 11466687 2001
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE The low frequency of CTNNB1 mutations, however, suggests that mutation of another Wnt signaling component, such as the Wnt scaffolding protein axin or the adenomatous polyposis coli protein, both of which modulate beta-catenin stability, also may be involved in aflatoxin-associated HCC.Published 2001 Wiley-Liss, Inc. 11429783 2001
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE In this study, we examined beta-catenin and APC mutations in 22 HCCs associated with HCV infection, using single-strand conformation polymorphism (SSCP) followed by direct DNA sequencing. beta-Catenin mutations were found in nine (41%) cases, but no APC mutations were found. beta-Catenin immunohistochemistry revealed nuclear accumulation of beta-catenin protein in all nine tumors with a beta-catenin mutation and two additional tumors without a mutation. 10595907 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.700 Biomarker disease BEFREE The results suggested that the possibility of APC and MCC as the gene defect in the genesis of human hepatocellular carcinoma may be very rare. 10381126 1998