Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Besides, examination of HCC clinical samples demonstrated that IL-6 and TNF-α production correlated with HPC activation, hepatic fibrosis, and HCC recurrence. 31065105 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE There were 3 papers in haematology and 2 in andrology, whilst 5 papers crossed traditional discipline boundaries (such as the molecular genetics of IL6, liver function tests, and hepatocellular carcinoma). 31818192 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Moreover, macrophage Six1 expression was able to induce interleukin-6 (IL-6) up-regulation and increase the activity of signal transducer and activator of transcription 3 (STAT3) in HCC cells, which accounted for the elevated levels of MMP-9 and the higher invasive levels seen in HCC. 31044528 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE And HSCs could secrete soluble factors, such as interleukin-6 (IL-6), vascular endothelial cell growth factor (VEGF), and stromal-derived factor-1 (SDF-1) to facilitate HCC progression. 30800209 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE We evaluated the expression of LOXL2 protein, in addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, and interleukin 6, in 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. 29938458 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Moreover, we found significantly decreased expression of IL-6 in the spleen as well as decreased NF-κB in the paraventricular nucleus of rats with Yoshida ascites hepatoma. 31606594 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE The results demonstrated that CKLF1 enhanced the progression of HCC and prevented doxorubicin-induced apoptosis through activating the IL6/STAT3 pathway. 30918019 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE We show that IL-6/STAT3 activation increases DNMT3b/1 and OCT4 in HCC. 31771617 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Tissues from patients with HCC and its paracarcinoma tissues were collected for IL-6 expression determination. 31387809 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Postintervention Interleukin-6 (IL-6) Level, Rather than the Pretreatment or Dynamic Changes of IL-6, as an Early Practical Marker of Tumor Response in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization. 31249138 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Furthermore, we detected lower levels of interleukin (IL)-35 in both types of transplanted hepatomas and higher level of IL-6 in orthotopically transplanted hepatomas following sFGL2 depletion. 31409352 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE In summary, HGF and IL6 secreted by CAFs promoted the stemness properties of CD24<sup>+</sup> cells through the phosphorylation of STAT3 signaling, and targeting the paracrine pathways may provide a new therapeutic strategy for HCC. 30564864 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma. 30648776 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE IL-6 and STAT3 signaling were inhibited in both HCC cell lines and non-tumor L-02 liver cells to further determine its role in the progression of HCC. 31118769 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Our results suggest IL-6 and HGF may be the key communication molecules for the interaction between LCSLCs and HSCs, and BrMC and chrysin could block these effects and be the novel therapeutic candidates for HCC management. 30866863 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE A murine-transplanted model of the liver tumor showed that HCCs cotransplanted with HSCs could significantly enhance the tumor area and detect more MDSCs compared with HCCs alone or HCCs cotransplanted with HSCs lacking IL-6. 31614930 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE Polymorphic genotypes predisposing the APOBEC3B-UNG imbalance in IL6-presenting microenvironment promote HCC development, possibly via promoting the generation of high-risk HBV mutations. 31152021 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE The inflammatory cytokines tumor necrosis factor-α and interleukin-6 and their downstream targets nuclear factor kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and signal transducer and activator of transcription 3 drive inflammation-associated HCC. 30809789 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE In this review, we give an overview about HCC pathogenesis with respect to IL-6-type cytokines and the Jak/STAT pathway. 31683891 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Macrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients. 31646099 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE In both sexes, reduced P1-HNF4α activity, which also occurs under chronic HF diet feeding, increased hepatic lipid deposition and produced a greatly augmented circadian rhythm in IL6, a factor previously linked with higher HCC incidence in males. 31575546 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Upregulation of IL-6 is involved in moderate hyperthermia induced proliferation and invasion of hepatocellular carcinoma cells. 29894725 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE We determined that crocin inhibited STAT3 activation induced by IL-6 in hepatocellular carcinoma Hep3B and HepG2 cells. 29393468 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Genetic deletion of NOR1 in mice leads to impairment of IL-6 production and NF-κB activation, which in turn attenuates DEN-induced HCC development. 29227538 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE The present study proposed that high IL-6 and IL-6R expression in the HCC microenvironment promotes postoperative tumor recurrence, suggesting that these may be potential predictors of recurrence, and may be used as possible therapeutic targets to enhance the long-term survival of patients. 30546452 2018