Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Overexpression of CPAP upregulates several STAT3 target genes such as IL-8 and CD44 that are involved in angiogenesis, and CPAP mRNA expression is positively correlated with the levels of both mRNAs in HCC. 31511651 2020
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE The rates of high IL-8 and ERK2 expression in HCC tissues were 43.28 (29/67) and 34.33% (23/67), respectively, and the IL-8 and ERK2 expression levels were positively correlated (r=0.764; P<0.001). 31612032 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Wound healing, transwell, and western blotting assay results showed that IL-8 promotes the migration and invasion of Huh-7 and HepG2 cells, and the underlying mechanism is that IL-8 induces the EMT of HCC cells via the IL-8/ERK1/2/SNAI1 and IL-8/STAT3/TWIST1 signalling pathways. 30903867 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Baseline HRQoL using the conventional assessments of EORTC QLQ-C30 and QLQ-HCC18, as well as C30 and HCC18 index-scores, significantly correlated with inflammatory indicators (IL-8 level and mIBI) in HCC patients. 31040713 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE RNA sequencing analysis revealed EMT inducers HIF1α/IL8 and Sox4 as potential mediators for the oncogenic effect of ABCF1 in HCC progression. 31100412 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE An inverse correlation between <i>PHB1</i> and <i>IL-8</i> mRNA levels is found in HCCs with reduced PHB1 expression. 30523154 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE IL-8 induced HCC cell invasion and integrin β3 expression was significantly inhibited by transfection with CXCR1 siRNA or CXCR2 siRNA. 31684995 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Changes in plasma interleukin-8 and TNF-α levels during the first few days could predict the response to sorafenib therapy in HCC patients. 30178114 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE IL-8, which promoted EMT and HCC invasion both <i>in vitro</i> and <i>in vivo</i>, was produced by NTS-induced HCC cells and was effectively attenuated by blocking IL-8 receptors <i>in vitro</i>. 29900041 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Multivariate analyses identified IL6 and IL8 as independent predictors of OS.<b>Conclusions:</b> Foretinib demonstrated promising antitumor activity and good tolerability in the first-line setting in Asian advanced hepatocellular carcinoma patients. 27821605 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE The expression of miR-18a and miR-19a (belonging to miR-17 cluster) increased in HCC cells by CXCL8 simulation and led to the enhancement of HCC cell proliferation and metastasis. 28559990 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE The objectives of the present study were: i) To investigate the association between soluble B7-H3 (sB7-H3) and cytokine levels of IL-17, IL-8 and IL-6 in the serum of patients with hepatocellular carcinoma (HCC); and ii) to determine their potential value for use in HCC diagnosis. 29344257 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin-8 expression. 28646551 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE By flow cytometry, we observed a significant IL-8 decrease which is closely related to the tumoral progression and chemotherapeutic resistance, especially in HCC. 28242545 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Expressions of glutathione S-transferase pi 1 (GSTP1), lysozyme (LYZ), C-X-C motif chemokine ligand 5 (CXCL5), interleukin-8 (IL8) and dickkopf WNT signaling pathway inhibitor 1 (DKK1), the five most highly expressed genes in the CSC cDNA microarray databases, were examined in 99 patients with HCC by real-time polymerase chain reaction (qRT-PCR), and their clinical significance was analyzed. 28870909 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice. 26065367 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Co-expression of HIF-1α and CXCL8 is a prognostic marker and a potential therapeutic target in HCC. 26078356 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE We found that IL-8: i) may induce EMT and promote HCC cell migration and invasion and ii) is associated with the JAK2/STAT3/Snail signaling pathway. 25405790 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE The serum level of IL8 was significantly higher in HCC patients compared with healthy controls (P < 0.001). 24381110 2014
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE EGF prompted the cell movement in both HepG2 and HCCLM3 and regulated the production of CXCL5 and CXCL8 from HCC, which were inhibited by EGFR inhibitor, Erk inhibitor (U0126), or PI3K inhibitors (BEZ-235 and SHBM1009). 24268047 2014
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE These findings indicate that shRNA-induced HIF-1α and IL-8 knockdown inhibit angiogenesis and tumour growth in HCC. 24321089 2014
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Both IL-8 and ABC transporters were highly expressed in xenograft and clinical HCC tissues, and knockdown of IL-8 significantly reduced tumour size in vivo. 24161763 2014
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Significantly increased IL-8 protein was confirmed in 90.91% of NTS(+) HCC samples and significantly positively correlated to the levels of NTS protein in cancer tissues (P = 0.036), which implied activation of NTS/IL-8 pathway in HCC. 23418512 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE In contrast, either interleukin-8 (IL-8) or basic fibroblast growth factor (bFGF) was upregulated in HCC. 23970062 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease BEFREE We hypothesize that the functional polymorphism of IL-8 may influence the inflammatory process during pathological stage from hepatitis to hepatocellular carcinoma (HCC). 22335768 2012