Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE MMP2 may act as an oncogene and may be a potential therapeutic target in HCC. 31157304 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2). 30685767 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Taken together, these data suggest that MEG3 regulates the PTEN/AKT/MMP-2/MMP-9 signaling axis and contributes to HCC development by targeting miRNA-10a-5p. 31396320 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE It was demonstrated that brucine inhibited vasculogenic mimicry which might be through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2 and matrix metalloproteinase-2 and metalloproteinase-9. 30723742 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase-2 in hepatocellular carcinoma cells and inhibits cell invasion. 30677226 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE We demonstrated the molecular mechanism by which MTA2 inhibits human HCC cell metastasis through the p38MAPK/MMP2 pathways, which might be helpful in determining the diagnostic value of this protein in patients with HCC. 31777601 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9. 30349190 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Our present study confirmed moderate hyperthermia treatment can promote the proliferation, migration and invasion of hepatocellular carcinoma (HCC) cells, which was evidenced by the results that moderate hyperthermia induced up regulation of proliferating cell nuclear antigen (PCNA) and matrix metalloproteinase-2 (MMP-2). 29894725 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Thus, tube-formation inhibition and MMP-2-mediated migration are likely to be important therapeutic targets of eupatilin in hepatocellular carcinoma metastasis. 30177376 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE The cases which were negative for ALCAM expression had shorter time to recurrence than positive cases, and univariate and multivariate survival analyses showed that ALCAM was an independent risk factor of HCC recurrence. qRT-PCR and Western blotting showed that the expression of EMT related genes (MMP-2, MMP-9, E-caherin and vimentin) significantly changed as a result of interfering or overexpression of ALCAM, and ALCAM was significantly associated with EMT in HCC. 29375378 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE CXCL10 accelerates EMT and metastasis by MMP-2 in hepatocellular carcinoma. 28670372 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Overexpression of HOXD-AS1 competitively bound to miR-130a-3p that prevented SOX4 from miRNA-mediated degradation, thus activated the expression of EZH2 and MMP2 and facilitated HCC metastasis. 28810927 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Positive correlation between CCR4 and MMP2 expression was also observed in HCC tissues. 28959024 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE With these results taken together, the current study demonstrates that inhibiting MMP-2 expression can enhance the antitumor effect of sorafenib in HCC cells with a high MMP-2 expression, which may provide a novel strategy to improve therapeutic efficiency in HCC. 28276313 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Moreover, miR-888-5p also increased the expression of MMP-2 and MMP-9 proteins which account for cell migration and invasion, and decreased the expression of p53 protein which further promoted malignance of HCC. 28337887 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE We also observed that HCC cell migration and upregulation of the level of MMP-2/9 and downregulation of E-cadherin induced by PGE2 were suppressed by FH535, an inhibitor of β-catenin. 27109804 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE In addition, ectopic expression of 14-3-3β in HCC cell lines led to enhanced migration ability and invasiveness, as well as up-regulation of matrix metalloproteinase 2 and 9, which could be suppressed by inhibiting the activation of Akt and nuclear factor-κB (NF-κB) signaling. 26730736 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE In hepatitis B-related HCC patients undergone palliative hepatectomy, those with higher MTSS1 mRNA expression accompanied by activation of matrix metalloproteinase 2 (MMP2) in residual HCC, had earlier residual HCC detection after hepatectomy and poorer survival when compared to those with lower MTSS1. 27230279 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Some clinical specimens of HCC also indicated that BDKRB2 and MMP2 were overexpressed. 27693494 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Moreover, EMT was reversed, MMP-2 expression was down-regulated, and migration ability of HCC cell was significantly inhibited when TGF-β receptor inhibitor SB431542 was added into the co-culture system. 27475525 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE In our study, we tested a matrix metalloproteinase-2 (MPP2) aCPP in delivering hTERT siRNA into hepatocellular carcinoma cells (SMMC-7721) to silence the hTERT gene. 25671640 2015
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Taken together, our results suggest that down-regulation of Gli-1 suppresses HCC cell migration and invasion likely through inhibiting expressions and activations of MMP-2, 9 and blocking EMT. 24792036 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE AMF produced by HCC was found to induce migration of different MSCs in vitro and to enhance their MMP2 activity. 24736611 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Together, our results link two drivers of invasion and metastasis in HCC and identify a novel pathway for MMP2 control. 25251472 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Silencing alpha-fetoprotein inhibits VEGF and MMP-2/9 production in human hepatocellular carcinoma cell. 24587407 2014