Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The result showed that LXRα was downregulated, whereas Glut1, PCNA, and MMP9 were upregulated in human HCC compared with normal liver. 30817182 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Recent studies have suggested a positive feedback loop between TGFβ1 and MMP-9 mediated by the PI3K signaling pathway that confers acquired invasion and metastasis in HCC via induction of the epithelial-mesenchymal transition (EMT), which grows into invasive carcinoma. 31499614 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The expression levels of CTNNB1 and MMP9 decreased by knocked down XRCC5 which may promote the progression of HCC via the Wnt/β-catenin signaling pathway. 31599408 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Finally, Western blot results indicated that silencing FBXO17 might function through downregulating the expression of proteins in wnt/β-catenin pathway such as c-Myc, MMP-9, and MMP-2 while upregulating GSK-3β level, thereby promoting the malignant progression of HCC. 31646557 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE This signal circuit was essential for regulating the expression of epithelial mesenchymal transition (EMT) factors, such as Snail, Zeb1, E-cadherin, and matrix metalloproteinase 9, involved in HCC cell migration and metastasis. 31387985 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The obtained data revealed that administration of Mel before MSCs treatment without preconditioning yielded a better ameliorative effect against DEN-induced hepatocellular carcinoma (HCC) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione S-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes Bax and caspase 3 and downregulated expression of anti-apoptotic genes Bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa B, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene. 30925457 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Moreover, macrophage Six1 expression was able to induce interleukin-6 (IL-6) up-regulation and increase the activity of signal transducer and activator of transcription 3 (STAT3) in HCC cells, which accounted for the elevated levels of MMP-9 and the higher invasive levels seen in HCC. 31044528 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Further investigations found that TFAP4 promotes invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway in HCC. 31281549 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Quantitative polymerase chain reaction, gelatin zymography and immunoblotting assay indicated that matrine could inhibit the activity of matrix metalloproteinase-9 without down-regulating its protein expression in HCC. 31126682 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE In the cell reverse experiment, the overexpression of MMP-9 could counteract the influence of the overexpressed microRNA-328-3p on proliferation and apoptosis in HCC cells, so as to regulate the malignant progression of HCC. 31773692 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Using tissue immunofluorescence studies, we also report that the expression of MMP-9 is significantly decreased in activated HSCs in fibrotic tissues associated with hepatocellular carcinoma. 31086224 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Taken together, we identified a novel IFITM3-p38/MAPK-MMP9 regulatory circuitry, the dysfunction of which drives invasive and metastatic character in HCC. 30087833 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Functional experiments revealed that MTP18 promoted both the growth and metastasis of HCC cells by inducing the progression of cell cycle, epithelial to mesenchymal transition (EMT) and production of MMP-9, and suppressing cell apoptosis. 30237394 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE In addition, miR-5692a promoted the malignant progression of HCC via regulating MMP9. 30070322 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE KIF18A may promote proliferation, invasion and metastasis of HCC cells by promoting the cell cycle signalling pathway as well as the Akt and MMP-7/MMP-9-related signalling pathways and may serve as a new target for the diagnosis and treatment of HCC. 29466986 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Wogonin Suppresses the Activity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion in Human Hepatocellular Carcinoma. 29439451 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Western blotting revealed that IL-20 promoted HCC progression through inducing transforming growth factor-β and matrix metalloproteinase 9 expression and enhancing the phosphorylation of Jun N-terminal kinase and signal transducer and activator of transcription 3. 30333881 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Therefore, HBV may take the advantage of MMP-9 function to establish or maintain chronic infection.<b>IMPORTANCE</b> Hepatitis B virus (HBV) infection may cause chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC). 28122987 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Moreover, miR-888-5p also increased the expression of MMP-2 and MMP-9 proteins which account for cell migration and invasion, and decreased the expression of p53 protein which further promoted malignance of HCC. 28337887 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Survival analysis of HCC patient's data indicated patients with a higher expression ratio of OCIAD2/MMP9 had a shorter overall survival than those with a lower expression ratio of OCIAD2/MMP9. 28911005 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Loss of Barx1 promotes hepatocellular carcinoma metastasis through up-regulating MGAT5 and MMP9 expression and indicates poor prognosis. 29069753 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE The Inhibitory Effect of C-phycocyanin Containing Protein Extract (C-PC Extract) on Human Matrix Metalloproteinases (MMP-2 and MMP-9) in Hepatocellular Cancer Cell Line (HepG2). 28357609 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The cases which were negative for ALCAM expression had shorter time to recurrence than positive cases, and univariate and multivariate survival analyses showed that ALCAM was an independent risk factor of HCC recurrence. qRT-PCR and Western blotting showed that the expression of EMT related genes (MMP-2, MMP-9, E-caherin and vimentin) significantly changed as a result of interfering or overexpression of ALCAM, and ALCAM was significantly associated with EMT in HCC. 29375378 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE FGFR3Δ7-9 also upregulated the metastasis-associated molecules Snail, MMP-9, and downregulated E-cadherin, which associated directly with FGFR3Δ7-9 Thus, as a ligand-dependent or -independent receptor, FGFR3Δ7-9 exerted multiple potent oncogenic functions in HCC cells, including proliferation, migration, and lung metastatic capacity. 27267910 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Collectively, crosstalk between HCC cells and HSCs promoted HCC chemoresistance and migration by increasing the expression of COL1A1 and MMP9 in MCTS. 27853186 2016