Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. 30723271 2019
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE SNPs in genes linked to HCC (DEPDC5, GRIK1, KIF1B, STAT4, MICA, DLC1, DDX18) or to liver damage (PNPLA3-rs738409, TM6SF2-rs58542926) in GWAS were genotyped in discovery cohorts including 1,020 HCC, 2,021 controls with chronic liver disease and 2,484 healthy individuals and replication was performed in prospective cohorts of cirrhotic patients with alcoholic liver disease (ALD, n = 249) and hepatitis C (n = 268). 30289982 2019
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE There was a significant correlation between DEPDC5 rs1012068A/C and HBV-related HCC in the Han Chinese population. 30683632 2019
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 AlteredExpression disease BEFREE Thus, DEPDC5 inactivation enhanced ROS resistance in HCC under the leucine-depleted conditions of chronic liver disease, contributing to poor patient outcome. 29311600 2018
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC). 28928439 2017
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE Interestingly, these genetic variants also affect the activity of hepatitis, or disease progression in chronic hepatitis C. In addition, polymorphisms in apoptosis-related genes such as RNF7, TULP1, and MERTK are associated with fibrosis progression, and DEPDC5 and MICA variants are associated with HCV-related hepatocellular carcinoma. 26211651 2016
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150). 26517016 2016
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE This study was conducted to assess the association of DEPDC5 variants with advanced liver cirrhosis and HCC development among chronic HCV-infected patients in Saudi Arabian population. 25551790 2014
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE Rs423058 upstream of PAPL, rs2834167 in IL10RB and rs1012068 in DEPDC5 were associated with chronic HBV status, HBV natural clearance and the presence of HCC (P = 0.0004–0.024), respectively. 25032264 2014
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368 2013
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 GeneticVariation disease BEFREE Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection. 21725309 2011
Entrez Id: 9681
Gene Symbol: DEPDC5
DEPDC5
0.500 Biomarker disease CTD_human Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection. 21725309 2011