Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy. 31105592 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, controlling hepatic oxidative stress and mediating hepatic inflammation through deacetylating some transcriptional regulators against the progression of fatty liver diseases. 28808418 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 GeneticVariation disease BEFREE In mice, hepatic deletion of Sirt1 promotes steatosis, inflammation, and fibrosis in response to ethanol challenge. 24262277 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The results revealed that the SIRT1/AMPK pathway is involved in the functions of the three flavonones, and the most effective flavonone against hepatic steatosis might be PCBG, followed by MPG and PCB. 30154382 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Therefore, we investigated whether the beneficial effects of exendin-4 treatment on fatty liver are mediated via Sirt1 in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models. 22363635 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. 28449683 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Resveratrol, a sirtuin 1 (SIRT1) agonist, prevents ER stress and improves ER stress-induced hepatic steatosis and cell death. 31183612 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.(Hepatology 2017;66:809-824). 28439947 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE This review will discuss the latest advances in this field, focusing on beneficial roles of SIRT1 in hepatic lipid metabolism including its potential as a therapeutic target for treatment of steatosis and other obesity-related metabolic diseases. 23374725 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Massive studies have suggested that liver steatosis is closely associated with the inhibition of silent information regulator 1 (SIRT1) and the augment of lipin1 β/α ratio mediated by ethanol. 28467182 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 GeneticVariation disease BEFREE Adenovirus-mediated liver-specific expression of SIRT1 or a phosphor-defective S164A-SIRT1 mutant promoted fatty acid oxidation and ameliorated liver steatosis and glucose intolerance in diet-induced obese mice, but these beneficial effects were not observed in mice expressing a phosphor-mimic S164D-SIRT1 mutant. 28533219 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis. 21540183 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE On the other hand, cells were transfected with miR-141 to investigate its effect on hepatocyte steatosis and viability as well as SIRT1 expression and activity along with AMPK phosphorylation. 31256424 2020
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE These results demonstrate that RSV restored leptin sensitivity in a cellular model of hepatic steatosis in a SIRT1-independent manner. 31842467 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The interaction of SIRT1/Mitofusin2 is critical for maintaining mitochondrial integrity and functioning, which is disrupted upon excess lipid infiltration during the progression of steatohepatitis. 28247434 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Several in vitro and in vivo studies have shown the known protective effects of SIRT1 activators, such as resveratrol and SRT1720, on diabetes- or obesity-induced fatty liver and insulin resistance. 29402742 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE These data show that SCD1 is involved in nucleotide (ATP and NAD<sup>+</sup> ) metabolism and suggest that the SCD1-dependent regulation of muscle steatosis and insulin sensitivity are mediated by cooperation between AMPK- and SIRT1-regulated pathways. 31241768 2020
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Molecularly, prevention of steatosis in the absence of REGγ entails elevated SirT1, a deacetylase regulating autophagy and metabolism. 24011073 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. 28667519 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE In comparison with placebo, GC significantly increased Sirt1 and decreased hs-CRP, TNF-α, IL-6, ALT, and the degree of fatty liver (<i>P</i> < 0.05). 30263038 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE APS treatment suppressed abnormal glycolipid metabolism and insulin resistance following 8 weeks of catch‑up growth by improving hepatic SIRT1‑PPARα‑FGF21 intracellular signaling and reducing chronic inflammation, and by partially attenuating hepatic steatosis. 26323321 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE Mice administered 0.02% scopolin for 8 weeks exhibited improved phenotypes of HFD-induced hepatic steatosis along with increased hepatic SIRT1 activity and protein expression. 28533555 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Besides hepatoprotective and metabolic beneficial effects, current study showed that elafibranor inhibited the progression of HFD-induced CKD through activation of renal PPAR<i>α</i>, PPAR<i>δ</i>, SIRT1, autophagy, reduction of oxidative stress, and apoptosis in mice with steatohepatitis. 31321239 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. 24486702 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway. 29595075 2018