Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE We therefore propose that the DBC1-SIRT1 interaction may serve as a new target for therapies aimed at nonalcoholic liver steatosis. 20071779 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE Downregulation of SIRT1 mRNA expression in VAT of SHS could be possible impairing mitochondria biogenesis and fatty acid oxidation, promoting severe steatosis in obese patients. 20033348 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis. 21540183 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Therefore, we investigated whether the beneficial effects of exendin-4 treatment on fatty liver are mediated via Sirt1 in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models. 22363635 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE This review will discuss the latest advances in this field, focusing on beneficial roles of SIRT1 in hepatic lipid metabolism including its potential as a therapeutic target for treatment of steatosis and other obesity-related metabolic diseases. 23374725 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Molecularly, prevention of steatosis in the absence of REGγ entails elevated SirT1, a deacetylase regulating autophagy and metabolism. 24011073 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 GeneticVariation disease BEFREE In mice, hepatic deletion of Sirt1 promotes steatosis, inflammation, and fibrosis in response to ethanol challenge. 24262277 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. 24486702 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE APS treatment suppressed abnormal glycolipid metabolism and insulin resistance following 8 weeks of catch‑up growth by improving hepatic SIRT1‑PPARα‑FGF21 intracellular signaling and reducing chronic inflammation, and by partially attenuating hepatic steatosis. 26323321 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE We are the first to demonstrate that the SIRT1/HMGB1 pathway is a key therapeutic target for controlling NAFLD inflammation and that SalB confers protection against HFD- and PA-induced hepatic steatosis and inflammation through SIRT1-mediated HMGB1 deacetylation. 26525891 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, controlling hepatic oxidative stress and mediating hepatic inflammation through deacetylating some transcriptional regulators against the progression of fatty liver diseases. 28808418 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. 28449683 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.(Hepatology 2017;66:809-824). 28439947 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Massive studies have suggested that liver steatosis is closely associated with the inhibition of silent information regulator 1 (SIRT1) and the augment of lipin1 β/α ratio mediated by ethanol. 28467182 2017