Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. 28449683 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Emerging roles of SIRT1 in fatty liver diseases. 28808418 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.(Hepatology 2017;66:809-824). 28439947 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE We are the first to demonstrate that the SIRT1/HMGB1 pathway is a key therapeutic target for controlling NAFLD inflammation and that SalB confers protection against HFD- and PA-induced hepatic steatosis and inflammation through SIRT1-mediated HMGB1 deacetylation. 26525891 2016
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. 24486702 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic overexpression of SIRT1 reduces steatosis and glucose intolerance in obese mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Prolonged fasting induced lipid deposition in livers of control mice, but severe hepatic steatosis in SIRT1 LKO mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Hepatic overexpression of FGF21 in SIRT1 LKO mice increased the expression of genes that regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased energy expenditure, and promoted browning of white adipose tissue. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Molecularly, prevention of steatosis in the absence of REGγ entails elevated SirT1, a deacetylase regulating autophagy and metabolism. 24011073 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic overexpression of FGF21 in SIRT1 LKO mice increased the expression of genes that regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased energy expenditure, and promoted browning of white adipose tissue. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Prolonged fasting induced lipid deposition in livers of control mice, but severe hepatic steatosis in SIRT1 LKO mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 GeneticVariation disease BEFREE In mice, hepatic deletion of Sirt1 promotes steatosis, inflammation, and fibrosis in response to ethanol challenge. 24262277 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Hepatic overexpression of SIRT1 reduces steatosis and glucose intolerance in obese mice. 24184811 2014