Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 AlteredExpression disease BEFREE After normalization of the steatosis-related circRNA by expression vector, analysis of miR-34a activity, peroxisome proliferator-activated receptor (PPAR)α level, and expression of downstream genes were carried out so as to reveal its impact on the miR-34a/PPARα regulatory system. 29391755 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease BEFREE Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in <i>Gynostemma pentaphylla</i> (Thunb.) Makino treated mice. 30555521 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease BEFREE Activating AMPK<i>α</i> negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPK<i>α</i> through mediating SIRT1 to suppress the development of fatty liver. 29681936 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease BEFREE These findings indicate a circRNA_0046367/miR-34a/PPAR<i>α</i> regulatory system underlying hepatic steatosis. 29018509 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 AlteredExpression disease BEFREE We found that hepatic miR-34a expression was upregulated in ethanol-fed mice and heavy drinkers with steatohepatitis compared with respective controls. 29128099 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 AlteredExpression disease BEFREE Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease. 26330104 2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease BEFREE Here we show that hepatocyte nuclear factor 4α (HNF4α), a liver-enriched nuclear hormone receptor, is markedly inhibited, whereas miR-34a is highly induced in patients with non-alcoholic steatohepatitis, diabetic mice and mice fed a high-fat diet. miR-34a is essential for HNF4α expression and regulates triglyceride accumulation in human and murine hepatocytes. miR-34a inhibits very low-density lipoprotein secretion and promotes liver steatosis and hypolipidemia in an HNF4α-dependent manner. 26100857 2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease BEFREE p53 and its transcriptional target miRNA34a have been implicated in the pathogenesis of fatty liver. 23211317 2013
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2013
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 Biomarker disease BEFREE MicroRNA-34a (miR-34a) is the most highly elevated hepatic miR in obese mice and is also substantially elevated in patients who have steatosis, but its role in obesity and metabolic dysfunction remains unclear. 22988100 2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.400 AlteredExpression disease BEFREE Again, miR-122 and miR-34a levels positively correlated with disease severity from simple steatosis to steatohepatitis. 21886843 2011