Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE The interferon antiviral pathways and prostate cancer genetics converge on a regulated endoribonuclease, RNase L. Positional cloning and linkage studies mapped Hereditary Prostate Cancer 1 (<i>HPC1</i>) to <i>RNASEL</i>. 28257035 2017
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease GENOMICS_ENGLAND Germline genetic profiling in prostate cancer: latest developments and potential clinical applications. 28031937 2016
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 SusceptibilityMutation disease ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE A role in tumor suppression was inferred by mapping of the RNase L gene to the hereditary prostate cancer 1 (HPC1) gene, which in turn led to discovery of the xenotropic murine leukemia-related virus. 21190483 2011
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 AlteredExpression disease BEFREE The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients. 20425007 2010
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE This effect is found for patients diagnosed with carcinoma of the uterine cervix, HNSCC, and breast cancer thus pointing at RNASEL as a general marker for cancer risk and not restricted to familial prostate cancer. 18575592 2008
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE Recently, RNase L was identified as the hereditary prostate cancer 1 gene. 17681844 2008
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls. 18767027 2008
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE The RNASEL gene at 1q25 has been identified as a hereditary prostate cancer susceptibility gene, but to date, no study has investigated the role of RNASEL variants in Hispanic Caucasian men with prostate cancer. 17908993 2007
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP17, CYP1B1, CYP3A4, GSTM1, GSTP1, GSTT1, PON1, SRD5A2, and VDR that have germline genetic variants associated with either hereditary and/or sporadic prostate cancer; and ANXA7 (ANX7), KLF5, NKX3-1 (NKX3.1), CDKN1B (p27), and MYC that have genomic copy number changes affecting gene function. 16267836 2006
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE RNASEL is thought to be a susceptibility gene for hereditary prostate cancer and encodes the endoribonuclease RNase L, which has a role in apoptosis and is a candidate tumour-suppressor protein. 16054567 2005
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested. 15981205 2005
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE In addition, the RNase L gene, RNASEL, was mapped to the hereditary prostate cancer 1 (HPC1) gene. 16241858 2005
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE Genetic studies have identified RNASEL, encoding an interferon inducible ribonuclease, and MSR1, encoding subunits of the macrophage scavenger receptor, as candidate inherited susceptibility genes for familial prostate cancer. 15535435 2004
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE The hereditary prostate cancer 1 (HPC1) allele maps to the RNASEL gene encoding a protein (RNase L) implicated in the antiviral activity of interferons. 15604285 2004
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE The RNASEL gene, a strong candidate for the hereditary prostate cancer 1 allele (HPC1), encodes a single-stranded specific endoribonuclease involved in the antiviral actions of IFNs. 14583476 2003
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE We screened for RNASEL germline mutations in familial prostate cancer patients, and performed a case-control study to examine the association of specific variants with prostate cancer risk in the Japanese. 12915880 2003
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE The ribonuclease L (RNase L) gene has been reported as the putative hereditary prostate cancer gene located at HPC1. 15040862 2003
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE Genetics studies from several laboratories in the U.S., Finland, and Israel, support the recent identification of the RNase L gene, RNASEL, as a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) allele. 12590567 2003
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE HPC1/RNASEL was recently identified as a candidate gene for hereditary prostate cancer. 12145743 2002
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE These results suggest that polymorphic changes within the RNASEL gene may be associated with increased risk of familial but not sporadic PC. 12022038 2002
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 GeneticVariation disease BEFREE Here we report that germline mutations in the gene encoding 2'-5'-oligoadenylate(2-5A)-dependent RNase L (RNASEL) segregate in prostate cancer families that show linkage to the HPC1 (hereditary prostate cancer 1) region at 1q24-25 (ref.9). 11799394 2002
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene. 12415269 2002
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
0.700 Biomarker disease BEFREE The RNASEL gene maps to the hereditary-prostate-cancer (HPC)-predisposition locus at 1q24-q25 (HPC1) and was recently shown to harbor truncating mutations in two families with linkage to HPC1. 11941539 2002