Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE Elevated HSP90 associates with expression of HIF-1α and p-AKT and is predictive of poor prognosis in nasopharyngeal carcinoma. 30882922 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Moreover, we explored whether HAGLROS modulated the expression of autophagy-related gene 14 (ATG14) by competitively sponging miR-100, and then regulated the briskness of PI3K/AKT/mTOR signals in NPC development. 31334669 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE This study aims to investigate the role of miR-144-3p and phosphatase and tensin homolog (PTEN) in nasopharyngeal carcinoma (NPC), along with their crosstalk with the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) pathway. 30834525 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE Furthermore, restoring <i>miR-141</i> expression could at least partially reverse the inhibitory effect of YY1 on cell proliferation and tumor growth and on the expression of some critical c-Myc targets, such as PTEN/AKT pathway components both <i>in vitro</i> and <i>in vivo</i> We also found that YY1 expression is reduced in NPC tissues, negatively correlates with <i>miR-141</i> expression and clinical stages in NPC patients, and positively correlates with survival prognosis. 30718276 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE These findings reveal that loss of NOTCH2 activates the TRAF6/AKT axis and promotes metastasis in NPC, suggesting that NOTCH2 may represent a therapeutic target for the treatment of NPC. 31699119 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Meanwhile, PI3K is positively correlated with PKB and PKB is positively correlated with mTOR in NPC. 30582216 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro. 31403940 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE In conclusion, the results demonstrated that triptolide suppressed the proliferation and induced the apoptosis of C666-1 cells in a PI3K/Akt-dependent manner and therefore, may serve as a promising therapeutic candidate for NPC. 30655908 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma. 30944308 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85. 29409973 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Both xenografts and clinical samples of NPC and EBVaGC exhibit VM histologically, which are correlated with AKT and HIF-1α activation. 30479336 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma. 30001734 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Our findings suggest that LASP1 has a crucial role in NPC progression via LASP1/PTEN/AKT axis, highlighting LASP1 as a therapeutic target for NPC. 29531214 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Inhibition of eEF-2 kinase may be an effective method for increasing the efficacy of an AKT inhibitor such as MK-2206 in NPC. 30214154 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE These results reveal a novel mechanism by which miR-296-3p negatively regulated by nicotine directly targets MK2-induced Ras/Braf/Erk/Mek/c-Myc or PI3K/AKT/c-Myc signaling to stimulate its own expression and suppress NPC cell proliferation and metastasis. miR-296-3p may thus serve as a therapeutic target to reverse chemotherapy resistance of NPC. 29525743 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Considering the mechanism of migration, NPC cells were cultured with AKT activator, revealing EGFL6 facilitated the progression of NPC via AKT. 30444069 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Correspondingly, an AKT inhibitor and rapamycin blocked the effect of EpCAM on NPC cell invasion and stem-like phenotypes, and siRNA targeting PTEN rescued the oncogenic activities in EpCAM knockdown NPC cells. 29305578 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Immunohistochemistry analysis also demonstrated that the PTEN-/p-AKT+/β-catenin+/Nanog+ axis may indicate poor prognosis and radioresistance in clinical NPC specimens. 29088815 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Our study thus identifies cMyc-miR-200c-PTEN-AKT as a functional module that promotes cellular transformation in nasopharyngeal carcinoma. 28029649 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE In this study, we demonstrate that Wnt/β-catenin and ALDH1A1 form a signal circuit and that NOR1 antagonizes the tumor stem cell-like phenotype in NPC cell lines: the ectopic overexpression of NOR1 reduced β-catenin and ALDH1A1 expression; β-catenin/TCF4 targeted the regulation of ALDH1A1 transcription in NPC cells; silencing ALDH1A1 reduced AKT (total and phosphorylated) and GSK-3β (phosphorylated) expression; and eventually feedback decreased β-catenin expression levels. 27891591 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. 28240350 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Functionally, p300-mediated Akt1 acetylation contributed to the proliferation of human NPC cells stimulated by IL-17A. 28588706 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Our findings demonstrate that the BRD7/miR-141/PTEN/AKT axis has critical roles in the progression of NPC and provide some promising targets for the diagnosis and treatment of NPC. 27010857 2016
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Collectively, our findings demonstrated that UBE2T is a possible diagnostic/prognostic biomarker for NPC and may promote the development and progression of NPC by activating the AKT/GSK3β/β-catenin pathway. 26943030 2016
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE This suggests that PI3K/AKT pathway has an important role in the induction and maintenance of CSC properties in NPC. 26568302 2016