Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.040 GeneticVariation disease BEFREE Association between variant amyloid deposits and motor deficits in FAD-associated presenilin-1 mutations: A systematic review. 26165445 2015
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.040 GeneticVariation disease BEFREE A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. 15122701 2004
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.040 GeneticVariation disease BEFREE Overexpression of the mutated PS1 gene produced amyloid plaques in the brain of transgenic mice. 9206974 1997
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.040 GeneticVariation disease BEFREE In this report, we demonstrate that transgenic animals that coexpress a FAD-linked human PS1 variant (A246E) and a chimeric mouse/human APP harboring mutations linked to Swedish FAD kindreds (APP swe) develop numerous amyloid deposits much earlier than age-matched mice expressing APP swe and wild-type Hu PS1 or APP swe alone. 9354339 1997