Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.040 AlteredExpression disease BEFREE Pretreatment of macrophages with synthetic LL-37 reduced MAP load and diminished the transcriptional expression of TNF-α and IFN-γ whereas increased IL-8. 31478135 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.040 Biomarker disease BEFREE Areas covered: This perspective is focused on elucidating the negative effects of using Anti-TNFα therapeutic agents as a treatment option in CD patients who are more likely suspected to have MAP infection, and the role of other immunomodulators in MAP infection. 28481651 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.040 AlteredExpression disease BEFREE Contrary to this, TNF-α levels were unchanged upon MAP stimulation regardless of NOD2 genotype and MAP solely activated NOD2- and Toll-like receptor (TLRs)-pathway with an enhanced production of interleukin (IL)-1β and IL-10. 25335775 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.040 Biomarker disease BEFREE The predominant induction of MAP dormant forms by Infliximab treatment may explain the lack of MAP reactivation during anti-TNF therapy of CD but does not exclude the possibility of MAP recrudescence after termination of therapy. 25702170 2015