Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE Gene set enrichment analysis revealed that the GFI1-SE deletion impaired NCD38-induced programs related to granulocyte differentiation and the CEBPA network, but restored NCD38-suppressed programs related to erythroid development, GATA1 targets, and acute myeloid leukemia (AML) clusters including FAB subtype M6 and AML with myelodysplastic syndrome-related chromosomal abnormalities. 31676828 2020
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE Genetic predispositions to myeloid malignancies can be classified into three categories: familial cancer syndromes associated with increased risk of various malignancies including myelodysplasia and acute myeloid leukemia such as Li-Fraumeni syndrome and constitutional mismatch repair deficiency (CMMRD); germline mutations conferring a specific increased risk of myelodysplastic syndrome and acute myeloid leukemia such as mutations in ANKRD26, CEBPA, DDX41, ETV6, GATA2, RUNX1, SRP72 genes; and finally primarily pediatric inherited bone marrow failure syndromes such as Fanconi anemia, dyskeratosis congenita, severe congenital neutropenia, Shwachman-Diamond syndrome and Diamond Blackfan anemia. 31203998 2019
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE Our approach indicated new molecular subtypes with differential survival and drug responsiveness among samples lacking fusion genes, including a novel myelodysplastic syndrome-like cluster and a cluster characterized with CEBPA mutations and differential activity of the S-adenosylmethionine-dependent DNA methylation pathway. 31329928 2019
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE Referral reasons included (1) bone marrow failure or myelodysplastic syndrome in patients ≤ 50 years, (2) evaluation for germ-line inheritance of identified RUNX1, GATA2, or CEBPA mutations on targeted next-generation sequencing panels, and (3) strong personal and/or family history of malignancy. 27210295 2016
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 Biomarker group BEFREE Our findings indicate that CEBPA methylation is a common event in MDS, but could not act as a prognostic biomarker for MDS patients. 26025484 2015
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. 26004809 2015
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 AlteredExpression group BEFREE Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia. 22851180 2012
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE Both mono- and bi-allelic CEBPA mutations were detected in acute myeloid leukaemia and myelodysplastic syndrome. 20492756 2010
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE CEBPA mutations cause a myeloid differentiation block and were detected in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), multiple myeloma and non-Hodgkin's lymphoma (NHL) patients. 19651529 2009
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group LHGDN CEBPA mutations were found in 14/152 (9.2%) of acute myeloid leukemia (AML) patients' samples, 6/143 (4.2%) of MDS patients' samples, 2/56 (3.6%) of non-Hodgkin's lymphoma (NHL) patients' samples and 2/39 (5.1%) of multiple myeloma (MM) patients' samples. 18182175 2008
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group BEFREE CEBPA mutations were found in 14/152 (9.2%) of acute myeloid leukemia (AML) patients' samples, 6/143 (4.2%) of MDS patients' samples, 2/56 (3.6%) of non-Hodgkin's lymphoma (NHL) patients' samples and 2/39 (5.1%) of multiple myeloma (MM) patients' samples. 18182175 2008
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 AlteredExpression group BEFREE Whereas multiple previous MDS genetic screens failed to identify altered expression of the gene encoding the myeloid transcription factor CEBPA, stage-specific and extensive down-regulation of CEBPA was specifically observed in MDS progenitors. 17616640 2007
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 GeneticVariation group LHGDN The emergence of a C/EBPalpha mutation in the clonal evolution of MDS towards secondary AML. 12592334 2003
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 AlteredExpression group BEFREE Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. 11830484 2002
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.400 CausalMutation group CGI